Detailed information of TA system TA064473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381516..3382152
• Replicon: chromosome
• Accession: NZ_CP016342
• Organism: Bordetella parapertussis strain H904

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: BBB43_RS15835
• Protein ID: WP_010928914.1
• Coordinates: 3381516..3381698 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: BBB43_RS15840
• Protein ID: WP_010928915.1
• Coordinates: 3381760..3382152 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBB43_RS15815	3377090..3377767	+	678	WP_010928910.1	HAD-IA family hydrolase	-
BBB43_RS15820	3377985..3379172	+	1188	WP_010928911.1	MFS transporter	-
BBB43_RS15830	3379747..3380967	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
BBB43_RS15835	3381516..3381698	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
BBB43_RS15840	3381760..3382152	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BBB43_RS15845	3382425..3383334	-	910	Protein_3139	LysR family transcriptional regulator	-
BBB43_RS15850	3383459..3384433	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
BBB43_RS15855	3384468..3384827	+	360	WP_010928917.1	hypothetical protein	-
BBB43_RS15860	3384894..3386066	+	1173	WP_010928918.1	thiolase domain-containing protein	-
BBB43_RS15865	3386070..3386496	+	427	Protein_3143	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379747..3380967	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T64473 WP_010928914.1 NZ_CP016342:3381516-3381698 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T64473 NZ_CP016342:3381516-3381698 [Bordetella parapertussis]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT64473 WP_010928915.1 NZ_CP016342:3381760-3382152 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT64473 NZ_CP016342:3381760-3382152 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0