Detailed information of TA system TA064472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2939449..2940062
• Replicon: chromosome
• Accession: NZ_CP016342
• Organism: Bordetella parapertussis strain H904

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: BBB43_RS13875
• Protein ID: WP_003811545.1
• Coordinates: 2939449..2939760 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BBB43_RS13880
• Protein ID: WP_003811547.1
• Coordinates: 2939763..2940062 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBB43_RS13850	2934601..2935155	-	555	Protein_2742	LamB/YcsF family protein	-
BBB43_RS13855	2935152..2936546	-	1395	WP_003811536.1	arylsulfatase	-
BBB43_RS13860	2936561..2937523	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
BBB43_RS13865	2937640..2938593	+	954	WP_041937234.1	LysR family transcriptional regulator	-
BBB43_RS13870	2938712..2939335	+	624	WP_003811542.1	glutathione S-transferase family protein	-
BBB43_RS13875	2939449..2939760	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBB43_RS13880	2939763..2940062	+	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
BBB43_RS13885	2940076..2942667	-	2592	WP_065956700.1	autotransporter domain-containing protein	-
BBB43_RS13890	2942797..2943471	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T64472 WP_003811545.1 NZ_CP016342:2939449-2939760 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T64472 NZ_CP016342:2939449-2939760 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT64472 WP_003811547.1 NZ_CP016342:2939763-2940062 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT64472 NZ_CP016342:2939763-2940062 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3