Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 2865441..2865650 | Replicon | chromosome |
Accession | NZ_CP016318 | ||
Organism | Clostridioides difficile strain 630 delta erm |
Toxin (Protein)
Gene name | CD2517.1 | Uniprot ID | Q182K5 |
Locus tag | CDIF630erm_RS20740 | Protein ID | WP_004454815.1 |
Coordinates | 2865492..2865650 (-) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | RCd8 | ||
Locus tag | - | ||
Coordinates | 2865441..2865575 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDIF630erm_RS13770 | 2861011..2862639 | + | 1629 | WP_004454813.1 | aspartate 4-decarboxylase | - |
CDIF630erm_RS13775 | 2862760..2863755 | + | 996 | WP_003431031.1 | asparaginase | - |
CDIF630erm_RS13780 | 2863933..2864316 | - | 384 | WP_011861577.1 | BlaI/MecI/CopY family transcriptional regulator | - |
- | 2865441..2865575 | + | 135 | NuclAT_4 | - | Antitoxin |
CDIF630erm_RS20740 | 2865492..2865650 | - | 159 | WP_004454815.1 | hypothetical protein | Toxin |
CDIF630erm_RS13795 | 2866009..2867379 | - | 1371 | WP_011861578.1 | cell wall-binding protein Cwp29 | - |
CDIF630erm_RS13800 | 2867593..2868711 | + | 1119 | WP_011861579.1 | site-specific integrase | - |
CDIF630erm_RS13805 | 2869028..2869696 | - | 669 | WP_011861580.1 | VanZ family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 5996.20 Da Isoelectric Point: 11.3102
>T64412 WP_004454815.1 NZ_CP016318:c2865650-2865492 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK
Download Length: 159 bp
>T64412 NZ_CP016318:c2865650-2865492 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA
Antitoxin
Download Length: 135 bp
>AT64412 NZ_CP016318:2865441-2865575 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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