Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 411723..412230 Replicon chromosome
Accession NZ_CP016305
Organism Rickettsia sp. MEAM1 (Bemisia tabaci) strain MEAM1

Toxin (Protein)


Gene name relE Uniprot ID A0A249E263
Locus tag BA173_RS02200 Protein ID WP_068041402.1
Coordinates 411967..412230 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A249E1M6
Locus tag BA173_RS02195 Protein ID WP_068041404.1
Coordinates 411723..411974 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA173_RS02175 407295..408899 + 1605 WP_068041408.1 bifunctional peptide chain release factor N(5)-glutamine methyltransferase PrmC/tRNA (guanosine(46)-N7)-methyltransferase TrmB -
BA173_RS02180 409200..409784 - 585 WP_016947716.1 ABC transporter substrate-binding protein -
BA173_RS02185 409796..410563 - 768 WP_016947717.1 VacJ family lipoprotein -
BA173_RS02190 410560..411573 - 1014 WP_016947718.1 methyltransferase domain-containing protein -
BA173_RS02195 411723..411974 + 252 WP_068041404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BA173_RS02200 411967..412230 + 264 WP_068041402.1 Txe/YoeB family addiction module toxin Toxin
BA173_RS02205 412459..413658 + 1200 WP_068041399.1 pyridoxal phosphate-dependent aminotransferase -
BA173_RS02210 413825..414481 + 657 WP_016947646.1 lysophospholipid acyltransferase family protein -
BA173_RS02215 414478..415734 + 1257 WP_016947647.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
BA173_RS02220 416223..416726 + 504 Protein_443 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10647.50 Da        Isoelectric Point: 10.0775

>T64389 WP_068041402.1 NZ_CP016305:411967-412230 [Rickettsia sp. MEAM1 (Bemisia tabaci)]
MIEVRWILEAAEDLAYWKKYDIKNYKRIKRLVKNIQETPFSGIGKPEPLKYSMTNLWSRRITHEHRLVYSIDAIEIIIYS
CRFHYKK

Download         Length: 264 bp

>T64389 NZ_CP016305:411967-412230 [Rickettsia sp. MEAM1 (Bemisia tabaci)]
ATGATTGAAGTTAGATGGATATTGGAGGCAGCAGAAGATTTAGCATATTGGAAAAAATATGACATTAAAAATTACAAACG
CATTAAACGCTTAGTAAAAAATATTCAAGAAACACCATTTAGTGGTATAGGTAAGCCAGAGCCTTTAAAATACTCAATGA
CTAATTTATGGTCTCGGAGAATTACTCATGAACATAGATTAGTATATTCTATTGATGCTATAGAAATTATAATATACTCT
TGTAGATTTCATTATAAAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9794.98 Da        Isoelectric Point: 6.2297

>AT64389 WP_068041404.1 NZ_CP016305:411723-411974 [Rickettsia sp. MEAM1 (Bemisia tabaci)]
MKSISSSSFRKNLSTVFDTVERDHIPYLVKRRNHTNLIIITEEEYESTKETLYLLSNPANADRLHEAIKRAERREFVEVN
LDD

Download         Length: 252 bp

>AT64389 NZ_CP016305:411723-411974 [Rickettsia sp. MEAM1 (Bemisia tabaci)]
ATGAAATCAATTAGTAGTTCTTCATTTAGAAAGAATCTAAGCACTGTGTTTGATACGGTGGAACGTGACCATATCCCTTA
TCTCGTAAAAAGAAGAAACCATACAAATCTTATTATTATAACAGAAGAAGAGTATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCGGCTAATGCTGATCGACTACACGAAGCCATCAAACGAGCAGAAAGAAGAGAATTTGTAGAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249E263

Antitoxin

Source ID Structure
AlphaFold DB A0A249E1M6

References