Detailed information of TA system TA064248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1981194..1981710
• Replicon: chromosome
• Accession: NZ_CP016159
• Organism: Klebsiella pneumoniae strain TH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: BAU11_RS09650
• Protein ID: WP_004178374.1
• Coordinates: 1981194..1981478 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BAU11_RS09655
• Protein ID: WP_064081307.1
• Coordinates: 1981468..1981710 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU11_RS09620	1976611..1976919	-	309	WP_002886907.1	PTS sugar transporter subunit IIB	-
BAU11_RS29590	1977004..1977177	+	174	WP_032416265.1	hypothetical protein	-
BAU11_RS09630	1977180..1977923	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
BAU11_RS09640	1978280..1980418	+	2139	WP_004222153.1	anaerobic ribonucleoside-triphosphate reductase	-
BAU11_RS09645	1980726..1981190	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BAU11_RS09650	1981194..1981478	-	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAU11_RS09655	1981468..1981710	-	243	WP_064081307.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BAU11_RS09660	1981788..1983698	-	1911	WP_009486549.1	BglG family transcription antiterminator	-
BAU11_RS09665	1983721..1984875	-	1155	WP_019704690.1	lactonase family protein	-
BAU11_RS09670	1984942..1985682	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T64248 WP_004178374.1 NZ_CP016159:c1981478-1981194 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T64248 NZ_CP016159:c1981478-1981194 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9076.56 Da
• Isoelectric Point: 6.3340

>AT64248 WP_064081307.1 NZ_CP016159:c1981710-1981468 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTQTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT64248 NZ_CP016159:c1981710-1981468 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACA
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A6THG1