Detailed information of TA system TA064230

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1266627..1266832
• Replicon: chromosome
• Accession: NZ_CP016106
• Organism: Clostridioides difficile strain DSM 29637

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: CDIF29637_RS06080
• Protein ID: WP_009896140.1
• Coordinates: 1266627..1266779 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1266759..1266832 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29637_RS06060	1262089..1262373	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
CDIF29637_RS06065	1262396..1263913	-	1518	WP_009896137.1	recombinase family protein	-
CDIF29637_RS06070	1264038..1264859	-	822	WP_009896138.1	tetratricopeptide repeat protein	-
CDIF29637_RS06075	1265050..1266477	+	1428	WP_021414333.1	cell wall-binding protein Cwp26	-
CDIF29637_RS06080	1266627..1266779	+	153	WP_009896140.1	hypothetical protein	Toxin
-	1266759..1266832	-	74	NuclAT_6	-	Antitoxin
CDIF29637_RS06085	1268600..1268824	-	225	WP_003438172.1	helix-turn-helix domain-containing protein	-
CDIF29637_RS06090	1269503..1269658	+	156	WP_021363414.1	hypothetical protein	-
CDIF29637_RS06100	1269904..1270155	+	252	WP_003419270.1	hypothetical protein	-
CDIF29637_RS06115	1271375..1271758	-	384	WP_003433385.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T64230 WP_009896140.1 NZ_CP016106:1266627-1266779 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T64230 NZ_CP016106:1266627-1266779 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT64230 NZ_CP016106:c1266832-1266759 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin