Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2725803..2727265 Replicon chromosome
Accession NZ_CP016029
Organism Legionella pneumophila strain Pontiac

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag A9P85_RS12165 Protein ID WP_061635450.1
Coordinates 2725803..2726660 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag A9P85_RS12170 Protein ID WP_014844518.1
Coordinates 2726657..2727265 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P85_RS12150 2721793..2722968 + 1176 WP_061773372.1 hypothetical protein -
A9P85_RS12155 2723251..2725002 - 1752 WP_061773373.1 DUF927 domain-containing protein -
A9P85_RS12160 2725085..2725360 - 276 WP_014844516.1 helix-turn-helix domain-containing protein -
A9P85_RS12165 2725803..2726660 - 858 WP_061635450.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A9P85_RS12170 2726657..2727265 - 609 WP_014844518.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
A9P85_RS12175 2727343..2727543 - 201 WP_027268450.1 hypothetical protein -
A9P85_RS12180 2727661..2728893 - 1233 WP_061773374.1 integrase family protein -
A9P85_RS12185 2729198..2730109 - 912 WP_014842316.1 site-specific integrase -
A9P85_RS12195 2730716..2730901 + 186 WP_014842318.1 hypothetical protein -
A9P85_RS12200 2730894..2731670 + 777 WP_014842319.1 methylase -
A9P85_RS12205 2731656..2732213 - 558 WP_014842320.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(37-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(7-93)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 31734.73 Da        Isoelectric Point: 6.2736

>T64163 WP_061635450.1 NZ_CP016029:c2726660-2725803 [Legionella pneumophila]
MTKDISASIRGRLKKIAKAEGSKSDFIAVLTRYGLERLLYRIGISEYASQFLLKGALLFNLWYDMPHRPTKDIDLLGFGD
NDLAYIQKTFREICSLSADDGMNFLSKSVEVSTIKKDGGYTGARVELFGELAKAKIKIQVDIGYGDAVTPGPIDANYPVL
LSDLPAPQIRTYPVYTVIAEKLHAIALLGMANSRLKDYLDLYVLLTQEQLDNQVLAQAIHATFIRRGMTVPEVLPVGLSD
EFANDPTRISIWNAFLSKNELEQRSLTEVIEVIISLIQTPFSLAK

Download         Length: 858 bp

>T64163 NZ_CP016029:c2726660-2725803 [Legionella pneumophila]
ATGACAAAAGATATAAGTGCTTCCATTCGAGGACGACTTAAAAAAATAGCAAAAGCTGAAGGATCAAAGTCAGATTTTAT
TGCTGTCTTAACCCGTTATGGTCTCGAGCGACTGTTATACCGAATTGGCATATCTGAATACGCCAGTCAATTTTTACTAA
AAGGTGCTTTGCTGTTTAATCTTTGGTATGACATGCCGCACCGCCCAACCAAGGATATTGATTTATTAGGGTTTGGTGAT
AATGATCTGGCTTATATCCAGAAAACTTTCAGGGAAATTTGTAGTCTTTCAGCGGACGATGGGATGAATTTTCTTTCTAA
ATCTGTTGAAGTAAGCACTATCAAAAAAGATGGTGGTTATACTGGTGCAAGGGTTGAGTTATTTGGAGAGTTGGCAAAAG
CAAAGATCAAAATACAAGTTGATATTGGTTATGGAGATGCAGTAACTCCTGGCCCAATAGACGCTAATTACCCTGTACTT
TTAAGCGATCTTCCTGCTCCACAAATTCGTACTTATCCCGTTTATACTGTTATCGCAGAAAAATTGCACGCAATTGCATT
ATTGGGTATGGCTAATAGTCGATTGAAAGATTACTTAGACCTTTATGTGTTATTAACTCAAGAACAATTGGATAATCAAG
TTTTAGCCCAAGCTATACATGCCACATTTATTCGTCGGGGCATGACTGTACCTGAAGTACTACCTGTAGGTCTGTCCGAT
GAATTCGCCAATGACCCAACTAGAATATCAATTTGGAACGCTTTTTTAAGCAAAAATGAATTGGAACAGAGATCATTAAC
AGAAGTTATAGAGGTGATCATAAGTTTAATTCAAACACCATTTTCTTTGGCAAAGTAA

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 22953.73 Da        Isoelectric Point: 9.2881

>AT64163 WP_014844518.1 NZ_CP016029:c2727265-2726657 [Legionella pneumophila]
MNTKNTHSQKALNLAKEKGIVRSSEFVEEGIPRIVISRLVANQQLQQIERGLYCLPEKEFSEKESLLVIATRVPQAIFCL
FTALQVHGLTTQLPRKIWIAMPIDSRVPKIDYPPIKMVKYSGEAYSQGIETQEADGVSFRVYNVAKTIADCFKHRNKIGM
DVAIEALKDAYAQNKVTADELWHYAKICRVAKVMRPYLEAIQ

Download         Length: 609 bp

>AT64163 NZ_CP016029:c2727265-2726657 [Legionella pneumophila]
ATGAATACTAAAAACACCCATAGTCAAAAGGCTCTGAATCTTGCTAAAGAAAAAGGAATCGTACGTTCCTCTGAGTTTGT
AGAAGAAGGCATTCCAAGAATCGTCATATCTCGTCTAGTTGCAAATCAACAATTGCAACAGATTGAGAGGGGGCTTTATT
GTCTTCCTGAAAAGGAATTCTCTGAAAAGGAGAGTTTGTTGGTTATTGCCACTCGAGTGCCACAAGCCATTTTTTGTCTT
TTTACAGCACTTCAAGTTCATGGACTTACTACACAATTGCCAAGAAAGATTTGGATAGCCATGCCTATTGATAGTCGTGT
ACCTAAAATAGATTATCCACCTATAAAAATGGTGAAGTATTCAGGAGAAGCTTATTCTCAGGGGATTGAAACGCAAGAGG
CAGATGGTGTTTCATTTCGTGTATATAATGTTGCTAAAACAATTGCTGATTGCTTTAAGCATAGGAATAAAATTGGTATG
GATGTAGCAATTGAAGCTTTGAAAGATGCTTATGCCCAAAATAAAGTGACTGCTGATGAACTATGGCATTATGCGAAAAT
TTGTCGTGTTGCAAAAGTAATGCGTCCTTATCTAGAGGCTATCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References