Detailed information of TA system TA064150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/DinJ(antitoxin)
• Location: 1109184..1109817
• Replicon: chromosome
• Accession: NZ_CP016019
• Organism: Bifidobacterium longum subsp. longum strain AH1206

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: V6XVY9
• Locus tag: BL1206_RS04995
• Protein ID: WP_023658269.1
• Coordinates: 1109184..1109552 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: V6XY43
• Locus tag: BL1206_RS05000
• Protein ID: WP_023658268.1
• Coordinates: 1109533..1109817 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1206_RS04945	1104809..1105066	+	258	WP_023658279.1	hypothetical protein	-
BL1206_RS04950	1105063..1105575	+	513	WP_023658278.1	hypothetical protein	-
BL1206_RS04955	1105662..1106270	+	609	WP_155759280.1	hypothetical protein	-
BL1206_RS04960	1106267..1106797	+	531	WP_069483780.1	hypothetical protein	-
BL1206_RS11300	1106794..1107030	+	237	WP_131206853.1	hypothetical protein	-
BL1206_RS04965	1107027..1107542	+	516	WP_069483781.1	hypothetical protein	-
BL1206_RS04970	1107539..1107805	+	267	WP_069483782.1	hypothetical protein	-
BL1206_RS04975	1108005..1108349	-	345	WP_069483783.1	hypothetical protein	-
BL1206_RS04980	1108346..1108558	-	213	WP_069483784.1	hypothetical protein	-
BL1206_RS04985	1108548..1108781	-	234	WP_069484012.1	hypothetical protein	-
BL1206_RS04990	1108778..1108996	-	219	WP_023658270.1	hypothetical protein	-
BL1206_RS04995	1109184..1109552	-	369	WP_023658269.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BL1206_RS05000	1109533..1109817	-	285	WP_023658268.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BL1206_RS05005	1109890..1110186	-	297	WP_023658267.1	hypothetical protein	-
BL1206_RS05010	1110277..1110459	-	183	WP_015713500.1	hypothetical protein	-
BL1206_RS05015	1110459..1110788	-	330	WP_015713499.1	hypothetical protein	-
BL1206_RS05020	1110790..1111536	-	747	WP_023658266.1	hypothetical protein	-
BL1206_RS05025	1111608..1111955	-	348	WP_069483785.1	hypothetical protein	-
BL1206_RS05030	1112150..1112494	-	345	WP_069483786.1	hypothetical protein	-
BL1206_RS05035	1112491..1112784	-	294	WP_069483787.1	hypothetical protein	-
BL1206_RS05040	1112884..1113309	-	426	WP_155759281.1	hypothetical protein	-
BL1206_RS05045	1113384..1113596	-	213	WP_069483789.1	hypothetical protein	-
BL1206_RS10790	1113717..1113905	-	189	WP_032742291.1	helix-turn-helix domain-containing protein	-
BL1206_RS05050	1114098..1114367	-	270	WP_015713494.1	hypothetical protein	-
BL1206_RS05055	1114381..1114647	-	267	WP_015713493.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1085459..1145614	60155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (16-111)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-52)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13892.83 Da
• Isoelectric Point: 4.8890

>T64150 WP_023658269.1 NZ_CP016019:c1109552-1109184 [Bifidobacterium longum subsp. longum]
MTSTPNEPRLYDVWLMWVEFPDHPGIGKPRPVVITEVDGDLVSGIVAKITGNTDWDEAGDVPLLDWKAEGLLKPSLVRCS
QRFYFNRSELLQWFGRLSLRDAEHVNDGLKATLDIPPYRRSV

Nucleotide

• Length: 369 bp

>T64150 NZ_CP016019:c1109552-1109184 [Bifidobacterium longum subsp. longum]
ATGACCAGTACGCCAAATGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
GAAGCCGCGTCCGGTGGTTATCACCGAGGTTGACGGCGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGTGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCGCTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTACAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGGTTGAAAGCCACATTGGACATTCCACCATACAGGCGAAGCGTATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10503.77 Da
• Isoelectric Point: 4.5582

>AT64150 WP_023658268.1 NZ_CP016019:c1109817-1109533 [Bifidobacterium longum subsp. longum]
MGKLVANVDDDVKARAAALYDSMGMSLSTAVNMFLRQSLVDNGLPFKPTRHTPDGYPVPPVHNAYMFERSEKGHVILPAD
WDDSEDDVYDQYAK

Nucleotide

• Length: 285 bp

>AT64150 NZ_CP016019:c1109817-1109533 [Bifidobacterium longum subsp. longum]
ATGGGTAAGCTGGTAGCCAATGTCGATGATGACGTCAAGGCGCGCGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCCGTCAACATGTTCCTACGCCAGTCTCTGGTGGACAACGGATTGCCGTTCAAGCCGACGCGACACACGCCGG
ACGGTTATCCGGTGCCGCCTGTTCACAATGCATACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGGATGATTCGGAGGATGATGTCTATGACCAGTACGCCAAATGA

Structures

Toxin

• AlphaFold DB: V6XVY9

Antitoxin

• AlphaFold DB: V6XY43