Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3317684..3318297 Replicon chromosome
Accession NZ_CP015925
Organism Legionella pneumophila strain E10_P

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A9E97_RS14695 Protein ID WP_070065791.1
Coordinates 3317977..3318297 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A9E97_RS14690 Protein ID WP_010948599.1
Coordinates 3317684..3317974 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9E97_RS15605 3313326..3313427 - 102 WP_077338794.1 hypothetical protein -
A9E97_RS14675 3313745..3315232 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
A9E97_RS14680 3315394..3316836 - 1443 WP_010948598.1 ATP-binding protein -
A9E97_RS14685 3317204..3317395 + 192 WP_014327021.1 hypothetical protein -
A9E97_RS14690 3317684..3317974 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
A9E97_RS14695 3317977..3318297 - 321 WP_070065791.1 hypothetical protein Toxin
A9E97_RS14700 3318502..3319005 - 504 WP_015443887.1 hypothetical protein -
A9E97_RS14705 3319115..3320161 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
A9E97_RS14710 3320465..3321427 - 963 WP_015443886.1 lytic murein transglycosylase -
A9E97_RS14715 3321957..3323135 + 1179 WP_010948604.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12350.11 Da        Isoelectric Point: 4.8949

>T63939 WP_070065791.1 NZ_CP015925:c3318297-3317977 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANCEKFDGHFKANGKRGGVRIIYYYVTPASQIRLL
LIYKKGIQDDLTTDQKKMLRQLNERW

Download         Length: 321 bp

>T63939 NZ_CP015925:c3318297-3317977 [Legionella pneumophila]
ATGATTTTTATTGAAACTCCAATTTTTACAGAAGACGTGAAGGAATTATTATCTGATGAGGAGTATGCTGAGTTTCAAGA
GTATCTTGCTGATAATCCTTTAGCTGGAGACGTAATTCAGCAAACTGGCAAACTGGCAAACTGCGAAAAGTTCGATGGTC
ATTTCAAGGCAAATGGGAAGCGAGGCGGTGTTAGAATTATTTATTATTATGTAACTCCTGCTTCACAAATAAGACTCTTA
CTTATTTATAAAAAAGGTATTCAAGATGATCTGACTACAGATCAAAAGAAAATGTTACGGCAATTAAATGAACGGTGGTA
A

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT63939 WP_010948599.1 NZ_CP015925:c3317974-3317684 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp

>AT63939 NZ_CP015925:c3317974-3317684 [Legionella pneumophila]
ATGGATAAAAAATTATTTGAACGATTATACGAAAGTATGACTCAGATGAACGAAATTATTGATGGTGAGCGTGTTCCTTC
ACGTGAGTTCGTAGTGGATGCTGTTCATGTAAAAGAAATTAGAAAAAAAACAGGCCTAACCCAAGAAAAATTTTGTCATT
TAATTGATGTAAGTATTGGAACATTAAGAAATTGGGAGCAGGGGAGAAGAGAGCCAACAGGTCCTGCAAAAGCTCTTCTT
CGCGCAATAAATAAAGATCCTGAACATGTATTAGCAGCATTAGCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References