Detailed information of TA system TA063795

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 930497..930722
• Replicon: chromosome
• Accession: NZ_CP015853
• Organism: Escherichia coli strain ATCC 43889

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: A8714_RS05050
• Protein ID: WP_000813254.1
• Coordinates: 930497..930652 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	930664..930722 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8714_RS05015	925782..926840	-	1059	WP_001303214.1	site-specific DNA-methyltransferase	-
A8714_RS05020	926991..927188	-	198	WP_000917735.1	hypothetical protein	-
A8714_RS05025	927415..928236	-	822	WP_000762902.1	antitermination protein	-
A8714_RS05030	928233..928607	-	375	WP_000904171.1	RusA family crossover junction endodeoxyribonuclease	-
A8714_RS05035	928620..929669	-	1050	WP_001265156.1	DUF968 domain-containing protein	-
A8714_RS05040	929671..929949	-	279	WP_072166534.1	hypothetical protein	-
A8714_RS05045	930019..930276	-	258	WP_001217394.1	hypothetical protein	-
A8714_RS05050	930497..930652	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	930664..930722	+	59	-	-	Antitoxin
A8714_RS05055	930898..931002	-	105	WP_001278450.1	hypothetical protein	-
A8714_RS05060	931118..931480	-	363	WP_000610377.1	DUF551 domain-containing protein	-
A8714_RS05065	931477..931848	-	372	WP_000137941.1	hypothetical protein	-
A8714_RS05070	931884..932096	-	213	WP_000063625.1	hypothetical protein	-
A8714_RS05075	932145..932501	-	357	WP_001302146.1	hypothetical protein	-
A8714_RS05080	932558..932953	-	396	WP_001118161.1	DUF977 family protein	-
A8714_RS05085	932969..933739	-	771	WP_000537576.1	DUF1627 domain-containing protein	-
A8714_RS05090	933774..934316	-	543	WP_157837342.1	replication protein	-
A8714_RS05095	934228..935268	-	1041	WP_000020570.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T63795 WP_000813254.1 NZ_CP015853:c930652-930497 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T63795 NZ_CP015853:c930652-930497 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT63795 NZ_CP015853:930664-930722 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin