Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3400188..3401023 Replicon chromosome
Accession NZ_CP015834
Organism Escherichia coli strain MS6198

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag MS6198_RS16715 Protein ID WP_001564063.1
Coordinates 3400646..3401023 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A1AEL8
Locus tag MS6198_RS16710 Protein ID WP_038432125.1
Coordinates 3400188..3400556 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6198_RS16670 3395847..3396527 + 681 WP_001278649.1 WYL domain-containing protein -
MS6198_RS16675 3396678..3397355 + 678 WP_001564058.1 hypothetical protein -
MS6198_RS16680 3397361..3397594 + 234 WP_001278293.1 DUF905 family protein -
MS6198_RS16685 3397684..3398502 + 819 WP_001175165.1 DUF945 domain-containing protein -
MS6198_RS16690 3398768..3399247 + 480 WP_033869257.1 antirestriction protein -
MS6198_RS16695 3399263..3399739 + 477 WP_001186774.1 RadC family protein -
MS6198_RS16700 3399804..3400025 + 222 WP_000692345.1 DUF987 domain-containing protein -
MS6198_RS16710 3400188..3400556 + 369 WP_038432125.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MS6198_RS16715 3400646..3401023 + 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
MS6198_RS31740 3401020..3401169 + 150 Protein_3200 hypothetical protein -
MS6198_RS31745 3401248..3401442 + 195 WP_024181941.1 DUF957 domain-containing protein -
MS6198_RS29115 3401527..3402369 + 843 Protein_3202 DUF4942 domain-containing protein -
MS6198_RS16740 3402711..3402881 + 171 Protein_3203 IS110 family transposase -
MS6198_RS16745 3403692..3404675 + 984 WP_001361242.1 KpsF/GutQ family sugar-phosphate isomerase -
MS6198_RS16750 3404747..3405895 + 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papX 3335941..3402496 66555
- flank IS/Tn - - 3402777..3402881 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T63618 WP_001564063.1 NZ_CP015834:3400646-3401023 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T63618 NZ_CP015834:3400646-3401023 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13569.31 Da        Isoelectric Point: 7.0369

>AT63618 WP_038432125.1 NZ_CP015834:3400188-3400556 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT63618 NZ_CP015834:3400188-3400556 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEL8

References