Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 36099..36658 | Replicon | plasmid p0157 |
| Accession | NZ_CP015816 | ||
| Organism | Escherichia coli O157:H7 strain JEONG-1266 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | O82928 |
| Locus tag | JEONG1266_RS28300 | Protein ID | WP_000421248.1 |
| Coordinates | 36099..36374 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C1J8K5 |
| Locus tag | JEONG1266_RS28305 | Protein ID | WP_001178089.1 |
| Coordinates | 36374..36658 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JEONG1266_RS28265 | 31452..31841 | - | 390 | WP_001172748.1 | cytochrome b562 family protein | - |
| JEONG1266_RS28270 | 31885..34095 | - | 2211 | WP_000592771.1 | catalase/peroxidase KatP | - |
| JEONG1266_RS28275 | 34272..34457 | + | 186 | WP_001302179.1 | hypothetical protein | - |
| JEONG1266_RS28280 | 34457..34873 | + | 417 | Protein_30 | IS91 family transposase | - |
| JEONG1266_RS30940 | 34873..35439 | + | 567 | Protein_31 | IS3-like element IS600 family transposase | - |
| JEONG1266_RS28290 | 35483..35698 | + | 216 | Protein_32 | transposase | - |
| JEONG1266_RS28295 | 35798..36004 | - | 207 | WP_001105064.1 | hypothetical protein | - |
| JEONG1266_RS28300 | 36099..36374 | - | 276 | WP_000421248.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JEONG1266_RS28305 | 36374..36658 | - | 285 | WP_001178089.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| JEONG1266_RS28310 | 37570..38427 | - | 858 | WP_000130945.1 | incFII family plasmid replication initiator RepA | - |
| JEONG1266_RS28315 | 38420..38494 | - | 75 | WP_001370046.1 | RepA leader peptide Tap | - |
| JEONG1266_RS28320 | 38730..38984 | - | 255 | WP_000083831.1 | replication regulatory protein RepA | - |
| JEONG1266_RS28325 | 39224..39562 | - | 339 | WP_000766796.1 | hypothetical protein | - |
| JEONG1266_RS28330 | 39600..39809 | - | 210 | WP_001302200.1 | hemolysin expression modulator Hha | - |
| JEONG1266_RS28335 | 39855..40316 | - | 462 | WP_001233856.1 | thermonuclease family protein | - |
| JEONG1266_RS28340 | 40561..40773 | - | 213 | WP_001302189.1 | ANR family transcriptional regulator | - |
| JEONG1266_RS28345 | 40906..41466 | - | 561 | WP_000840472.1 | fertility inhibition protein FinO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | exeG / exeE / stcE / espP / toxB / hlyD / hlyB / hlyA / hlyC | 1..95910 | 95910 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10735.42 Da Isoelectric Point: 9.9324
>T63479 WP_000421248.1 NZ_CP015816:c36374-36099 [Escherichia coli O157:H7]
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T63479 NZ_CP015816:c36374-36099 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10474.89 Da Isoelectric Point: 5.6558
>AT63479 WP_001178089.1 NZ_CP015816:c36658-36374 [Escherichia coli O157:H7]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT63479 NZ_CP015816:c36658-36374 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Z6FAZ0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731IHA8 |