Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3097658..3098262 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag SZ58_RS15220 Protein ID WP_003414492.1
Coordinates 3097658..3098050 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag SZ58_RS15225 Protein ID WP_003414495.1
Coordinates 3098047..3098262 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS15190 3092812..3093600 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
SZ58_RS15195 3093934..3094479 - 546 WP_003904931.1 DUF1802 family protein -
SZ58_RS15200 3094751..3095635 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
SZ58_RS15205 3095638..3096525 - 888 WP_044291448.1 type IV toxin-antitoxin system AbiEi family antitoxin -
SZ58_RS15210 3096830..3097371 - 542 Protein_2867 DUF1802 family protein -
SZ58_RS15215 3097368..3097637 - 270 WP_003414489.1 DUF2277 family protein -
SZ58_RS15220 3097658..3098050 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
SZ58_RS15225 3098047..3098262 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SZ58_RS15230 3098309..3099058 + 750 WP_003414497.1 enoyl-CoA hydratase -
SZ58_RS15235 3099137..3100219 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
SZ58_RS15240 3100212..3101522 - 1311 WP_031702645.1 ABC transporter substrate-binding protein -
SZ58_RS15245 3101525..3102352 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
SZ58_RS15250 3102349..3103260 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T63449 WP_003414492.1 NZ_CP015773:c3098050-3097658 [Mycobacterium tuberculosis variant bovis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T63449 NZ_CP015773:c3098050-3097658 [Mycobacterium tuberculosis variant bovis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT63449 WP_003414495.1 NZ_CP015773:c3098262-3098047 [Mycobacterium tuberculosis variant bovis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT63449 NZ_CP015773:c3098262-3098047 [Mycobacterium tuberculosis variant bovis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References