Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2901650..2902364 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag SZ58_RS14075 Protein ID WP_003413460.1
Coordinates 2901924..2902364 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag SZ58_RS14070 Protein ID WP_003413456.1
Coordinates 2901650..2901937 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS14035 2897072..2897317 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SZ58_RS14040 2897314..2897718 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
SZ58_RS14045 2897935..2898555 + 621 WP_003413441.1 DUF4178 domain-containing protein -
SZ58_RS14050 2898566..2899060 + 495 WP_003413444.1 DUF2617 family protein -
SZ58_RS14055 2899057..2899488 + 432 WP_003413445.1 DUF4247 domain-containing protein -
SZ58_RS14060 2899513..2899971 + 459 WP_003413451.1 DUF350 domain-containing protein -
SZ58_RS14065 2899968..2901539 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
SZ58_RS14070 2901650..2901937 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
SZ58_RS14075 2901924..2902364 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
SZ58_RS14080 2902385..2903140 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
SZ58_RS14085 2903273..2903869 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
SZ58_RS14090 2903877..2904722 - 846 WP_010950749.1 acyl-CoA thioesterase II -
SZ58_RS14095 2904751..2905650 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
SZ58_RS14100 2905778..2906452 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T63444 WP_003413460.1 NZ_CP015773:2901924-2902364 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T63444 NZ_CP015773:2901924-2902364 [Mycobacterium tuberculosis variant bovis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT63444 WP_003413456.1 NZ_CP015773:2901650-2901937 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT63444 NZ_CP015773:2901650-2901937 [Mycobacterium tuberculosis variant bovis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References