Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2841309..2841946 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag SZ58_RS13790 Protein ID WP_003413180.1
Coordinates 2841309..2841704 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag SZ58_RS13795 Protein ID WP_003413183.1
Coordinates 2841701..2841946 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS13750 2837394..2838053 + 660 WP_003900846.1 LppA family lipoprotein -
SZ58_RS13755 2838050..2838709 + 660 WP_003900847.1 hypothetical protein -
SZ58_RS13760 2838706..2839368 + 663 WP_003900848.1 hypothetical protein -
SZ58_RS13765 2839365..2839643 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
SZ58_RS13770 2839736..2840149 + 414 WP_003413164.1 PIN domain nuclease -
SZ58_RS13775 2840188..2840445 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
SZ58_RS13780 2840442..2840819 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
SZ58_RS13785 2840835..2841209 - 375 WP_003413177.1 hypothetical protein -
SZ58_RS13790 2841309..2841704 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
SZ58_RS13795 2841701..2841946 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
SZ58_RS13805 2842357..2842776 - 420 WP_003413190.1 A24 family peptidase -
SZ58_RS13810 2842788..2843615 - 828 WP_010950736.1 shikimate dehydrogenase -
SZ58_RS13815 2843593..2844846 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
SZ58_RS13820 2844839..2845351 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T63443 WP_003413180.1 NZ_CP015773:c2841704-2841309 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T63443 NZ_CP015773:c2841704-2841309 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT63443 WP_003413183.1 NZ_CP015773:c2841946-2841701 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT63443 NZ_CP015773:c2841946-2841701 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References