Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2840188..2840819 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag SZ58_RS13780 Protein ID WP_003413174.1
Coordinates 2840442..2840819 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag SZ58_RS13775 Protein ID WP_003413167.1
Coordinates 2840188..2840445 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS13735 2835446..2835760 + 315 WP_009937839.1 hypothetical protein -
SZ58_RS13740 2836056..2837267 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
SZ58_RS13750 2837394..2838053 + 660 WP_003900846.1 LppA family lipoprotein -
SZ58_RS13755 2838050..2838709 + 660 WP_003900847.1 hypothetical protein -
SZ58_RS13760 2838706..2839368 + 663 WP_003900848.1 hypothetical protein -
SZ58_RS13765 2839365..2839643 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
SZ58_RS13770 2839736..2840149 + 414 WP_003413164.1 PIN domain nuclease -
SZ58_RS13775 2840188..2840445 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
SZ58_RS13780 2840442..2840819 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
SZ58_RS13785 2840835..2841209 - 375 WP_003413177.1 hypothetical protein -
SZ58_RS13790 2841309..2841704 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
SZ58_RS13795 2841701..2841946 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
SZ58_RS13805 2842357..2842776 - 420 WP_003413190.1 A24 family peptidase -
SZ58_RS13810 2842788..2843615 - 828 WP_010950736.1 shikimate dehydrogenase -
SZ58_RS13815 2843593..2844846 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
SZ58_RS13820 2844839..2845351 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T63442 WP_003413174.1 NZ_CP015773:2840442-2840819 [Mycobacterium tuberculosis variant bovis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T63442 NZ_CP015773:2840442-2840819 [Mycobacterium tuberculosis variant bovis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT63442 WP_003413167.1 NZ_CP015773:2840188-2840445 [Mycobacterium tuberculosis variant bovis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT63442 NZ_CP015773:2840188-2840445 [Mycobacterium tuberculosis variant bovis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References