Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704545..705188 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag SZ58_RS03245 Protein ID WP_003403187.1
Coordinates 704787..705188 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag SZ58_RS03240 Protein ID WP_003403184.1
Coordinates 704545..704790 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS03205 699825..700355 - 531 WP_003917320.1 two component system sensor kinase HK2 -
SZ58_RS03210 700339..701034 - 696 WP_197044064.1 response regulator transcription factor -
SZ58_RS03215 701157..701468 + 312 WP_003403164.1 hypothetical protein -
SZ58_RS03220 701540..702490 + 951 WP_003907436.1 DUF1259 domain-containing protein -
SZ58_RS03225 702731..703315 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
SZ58_RS03230 703317..704027 + 711 Protein_626 transposase -
SZ58_RS03235 704030..704500 + 471 WP_003898523.1 hypothetical protein -
SZ58_RS03240 704545..704790 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SZ58_RS03245 704787..705188 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
SZ58_RS21555 705576..705743 - 168 WP_077385191.1 DUF3800 domain-containing protein -
SZ58_RS21560 705776..705973 - 198 WP_003403191.1 hypothetical protein -
SZ58_RS03270 706053..707210 - 1158 WP_003403193.1 hypothetical protein -
SZ58_RS03275 707262..707483 - 222 WP_003898525.1 DUF4926 domain-containing protein -
SZ58_RS03280 707625..708230 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T63406 WP_003403187.1 NZ_CP015773:704787-705188 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T63406 NZ_CP015773:704787-705188 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT63406 WP_003403184.1 NZ_CP015773:704545-704790 [Mycobacterium tuberculosis variant bovis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT63406 NZ_CP015773:704545-704790 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References