Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71619..72252 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag SZ58_RS00360 Protein ID WP_003400580.1
Coordinates 71851..72252 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BR76
Locus tag SZ58_RS00355 Protein ID WP_011799070.1
Coordinates 71619..71858 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS00345 66916..68355 + 1440 WP_003901784.1 FAD-binding oxidoreductase -
SZ58_RS21085 68411..68572 + 162 WP_003899796.1 hypothetical protein -
SZ58_RS00350 68613..71552 + 2940 WP_003901785.1 UPF0182 family protein -
SZ58_RS00355 71619..71858 + 240 WP_011799070.1 hypothetical protein Antitoxin
SZ58_RS00360 71851..72252 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
SZ58_RS00365 72304..74541 - 2238 WP_003400583.1 NADP-dependent isocitrate dehydrogenase -
SZ58_RS00370 74659..75228 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
SZ58_RS00375 75331..76242 + 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T63398 WP_003400580.1 NZ_CP015773:71851-72252 [Mycobacterium tuberculosis variant bovis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T63398 NZ_CP015773:71851-72252 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8745.89 Da        Isoelectric Point: 8.5960

>AT63398 WP_011799070.1 NZ_CP015773:71619-71858 [Mycobacterium tuberculosis variant bovis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEVIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT63398 NZ_CP015773:71619-71858 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BR76

References