Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4564095..4564768 Replicon chromosome
Accession NZ_CP015736
Organism Shinella sp. HZN7

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A9G5V2
Locus tag shn_RS21870 Protein ID WP_064332280.1
Coordinates 4564346..4564768 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3XGK1
Locus tag shn_RS21865 Protein ID WP_012110103.1
Coordinates 4564095..4564349 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
shn_RS21855 4561699..4562733 + 1035 WP_064332278.1 toprim domain-containing protein -
shn_RS21860 4563082..4564008 + 927 WP_064332279.1 DUF2493 domain-containing protein -
shn_RS21865 4564095..4564349 + 255 WP_012110103.1 plasmid stabilization protein Antitoxin
shn_RS21870 4564346..4564768 + 423 WP_064332280.1 type II toxin-antitoxin system VapC family toxin Toxin
shn_RS36505 4565050..4565217 + 168 WP_168168942.1 hypothetical protein -
shn_RS21875 4565352..4565792 + 441 WP_064332743.1 hypothetical protein -
shn_RS21880 4566365..4566691 + 327 WP_041535876.1 DUF736 domain-containing protein -
shn_RS21885 4566998..4567264 + 267 WP_045811379.1 helix-turn-helix transcriptional regulator -
shn_RS35170 4567319..4567621 + 303 WP_082653054.1 DUF2285 domain-containing protein -
shn_RS21895 4567983..4568513 + 531 WP_064332282.1 DUF2285 domain-containing protein -
shn_RS21900 4568650..4568931 + 282 WP_012110094.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14985.14 Da        Isoelectric Point: 4.5093

>T63330 WP_064332280.1 NZ_CP015736:4564346-4564768 [Shinella sp. HZN7]
MILLDTNVVSEAMKPAPDEAVRAWLDEQAAETLFLSSVTIAELMFGIGALPDGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARTAGKGFPTPDGYIAAIAAAKGFAVATRDNSAFEAANVTVIDPWKAGR

Download         Length: 423 bp

>T63330 NZ_CP015736:4564346-4564768 [Shinella sp. HZN7]
ATGATCCTCCTCGACACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGCGGCGGAAACACTCTTTCTCTCCAGCGTCACCATCGCCGAGCTGATGTTCGGCATCGGCGCGCTCCCCGATGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTACGCGGATCTCGCCGTCAAAGCCCGAACGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTATATCGC
GGCGATCGCCGCCGCCAAGGGCTTTGCCGTCGCCACGCGCGACAACAGCGCATTCGAGGCTGCGAATGTCACGGTCATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9351.67 Da        Isoelectric Point: 10.4317

>AT63330 WP_012110103.1 NZ_CP015736:4564095-4564349 [Shinella sp. HZN7]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Download         Length: 255 bp

>AT63330 NZ_CP015736:4564095-4564349 [Shinella sp. HZN7]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCACCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCTCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9G5V2

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XGK1

References