Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1403369..1404015 Replicon chromosome
Accession NZ_CP015736
Organism Shinella sp. HZN7

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A9G0F1
Locus tag shn_RS06765 Protein ID WP_064329728.1
Coordinates 1403623..1404015 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A9FZQ0
Locus tag shn_RS06760 Protein ID WP_064329727.1
Coordinates 1403369..1403623 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
shn_RS06740 1399950..1401101 - 1152 WP_145926000.1 GNAT family N-acetyltransferase -
shn_RS06745 1401373..1401816 + 444 WP_064329724.1 NUDIX domain-containing protein -
shn_RS06750 1401818..1402015 - 198 WP_084437827.1 DUF2842 domain-containing protein -
shn_RS06755 1402236..1403315 + 1080 WP_064329726.1 COX15/CtaA family protein -
shn_RS06760 1403369..1403623 + 255 WP_064329727.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
shn_RS06765 1403623..1404015 + 393 WP_064329728.1 type II toxin-antitoxin system VapC family toxin Toxin
shn_RS06770 1404023..1404955 - 933 WP_064329729.1 N-acetyl-gamma-glutamyl-phosphate reductase -
shn_RS06775 1405089..1406042 - 954 WP_064329730.1 agmatinase -
shn_RS06780 1406173..1406649 - 477 WP_064329731.1 30S ribosomal protein S9 -
shn_RS06785 1406652..1407116 - 465 WP_064329732.1 50S ribosomal protein L13 -
shn_RS06790 1407346..1407777 - 432 WP_064329733.1 PaaI family thioesterase -
shn_RS06795 1407916..1408731 + 816 WP_064329734.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-122)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13709.59 Da        Isoelectric Point: 4.2062

>T63326 WP_064329728.1 NZ_CP015736:1403623-1404015 [Shinella sp. HZN7]
MVIDTSALAAVLFQEDDAAIFEEMLATGGRCLISAVTRVEVTCVIEGRKGEEGRAALEALLDAVSAETVSVDGAQVNLAI
SGFRTYGKERHPAGLNIGDCFSYALAKALDEPLLFKGNDFALTDIRSALA

Download         Length: 393 bp

>T63326 NZ_CP015736:1403623-1404015 [Shinella sp. HZN7]
ATGGTCATCGACACCTCGGCGCTCGCGGCCGTGCTGTTTCAGGAAGATGACGCGGCAATCTTCGAGGAGATGCTGGCAAC
TGGCGGGCGATGCCTGATTTCCGCCGTCACACGCGTCGAAGTCACCTGTGTGATCGAAGGAAGAAAGGGCGAAGAAGGGC
GTGCCGCGTTGGAGGCGCTGCTGGATGCGGTGAGCGCCGAGACCGTCTCGGTCGATGGCGCTCAGGTCAATCTCGCTATT
TCCGGCTTTCGTACCTATGGCAAGGAAAGGCATCCGGCAGGCCTGAATATCGGCGACTGCTTTTCCTACGCGCTCGCAAA
GGCTCTCGACGAGCCCTTGCTGTTCAAGGGCAACGATTTCGCCCTGACGGATATACGCTCCGCGCTTGCCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9202.36 Da        Isoelectric Point: 8.0202

>AT63326 WP_064329727.1 NZ_CP015736:1403369-1403623 [Shinella sp. HZN7]
MALSLKDAETDRLAREVAALTGESLTTAIRKALAERLDRERRRRGQPSDLKRRLHAIGAACAALPDRDGRSADDIVGYDG
DGLW

Download         Length: 255 bp

>AT63326 NZ_CP015736:1403369-1403623 [Shinella sp. HZN7]
ATGGCACTCAGCCTGAAGGATGCCGAAACGGATCGGCTCGCCCGCGAAGTGGCCGCCTTGACCGGTGAGAGCCTGACGAC
GGCGATCCGCAAGGCGCTTGCCGAGCGTCTCGACCGGGAACGCCGCCGCCGCGGCCAGCCGTCCGATCTGAAACGTCGCC
TGCACGCGATCGGTGCCGCCTGCGCGGCGCTGCCCGACAGGGACGGCCGCTCCGCGGACGACATCGTCGGCTATGATGGC
GACGGGCTCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9G0F1

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9FZQ0

References