Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4002663..4003318 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1KUT7
Locus tag Q5A_RS18550 Protein ID WP_006318241.1
Coordinates 4002663..4003052 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1KUW5
Locus tag Q5A_RS18555 Protein ID WP_006318240.1
Coordinates 4003055..4003318 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS18535 3999140..4000573 + 1434 WP_006318248.1 MFS transporter -
Q5A_RS18540 4000570..4001952 + 1383 WP_006318242.1 two-component system sensor histidine kinase BaeS -
Q5A_RS18545 4001952..4002668 + 717 WP_004951961.1 two-component system response regulator BaeR -
Q5A_RS18550 4002663..4003052 - 390 WP_006318241.1 type II toxin-antitoxin system VapC family toxin Toxin
Q5A_RS18555 4003055..4003318 - 264 WP_006318240.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Q5A_RS18560 4003669..4004007 + 339 WP_006318239.1 YegP family protein -
Q5A_RS18565 4004243..4005595 + 1353 WP_043912278.1 tRNA 5-hydroxyuridine modification protein YegQ -
Q5A_RS18570 4006086..4006985 + 900 WP_006318237.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14048.36 Da        Isoelectric Point: 7.8817

>T63262 WP_006318241.1 NZ_CP015613:c4003052-4002663 [Serratia inhibens PRI-2C]
MYMFDTNTVSHLFRRHPGLLSAMEKVPPSTVCISSITEAELLFGVAKRQSKALKAMVTAFLAAVTVYDWDSEAARCYGVM
RASMEKKGKVLGALDQLIAAHALSRGATMVTSDRAFGMVSGLDVEDWTL

Download         Length: 390 bp

>T63262 NZ_CP015613:c4003052-4002663 [Serratia inhibens PRI-2C]
ATGTATATGTTTGACACCAATACCGTGAGCCACCTGTTTCGCCGGCACCCAGGTTTGCTGAGTGCGATGGAAAAGGTGCC
GCCTTCCACCGTATGCATTTCCAGCATCACGGAGGCGGAGCTGCTTTTTGGCGTGGCCAAACGGCAGAGTAAAGCGTTGA
AAGCCATGGTAACGGCGTTTTTAGCCGCGGTGACCGTTTATGACTGGGATAGCGAAGCTGCCCGCTGTTATGGCGTAATG
CGGGCGAGCATGGAGAAAAAAGGCAAAGTCCTGGGCGCGCTGGACCAGTTGATTGCCGCGCATGCGCTTAGCCGGGGCGC
GACAATGGTCACTAGCGATCGGGCCTTCGGCATGGTGTCCGGGCTGGACGTTGAAGACTGGACCCTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10140.43 Da        Isoelectric Point: 4.8950

>AT63262 WP_006318240.1 NZ_CP015613:c4003318-4003055 [Serratia inhibens PRI-2C]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWEPLLNIIAKTPVPHDFLGADERQQGIADR
DPFAEEE

Download         Length: 264 bp

>AT63262 NZ_CP015613:c4003318-4003055 [Serratia inhibens PRI-2C]
ATGGAAAGAATCGCAAAGCTGTTTAAAAATGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTTGAATTTGACACAGA
CCGCGTGTATATCCGCCGCGATCGGGAGGGGAATGTGATTTTATCTAAATACCCGGCAAAACCGGACAGTTGGGAGCCGC
TGTTGAACATCATCGCCAAAACGCCGGTACCGCATGATTTTCTGGGCGCGGATGAACGCCAACAGGGCATTGCCGACCGG
GATCCTTTCGCAGAGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUT7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUW5

References