Detailed information of TA system TA063245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 207824..208297
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Q5A_RS00925
• Protein ID: WP_006318279.1
• Coordinates: 208022..208297 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B1KJS6
• Locus tag: Q5A_RS00920
• Protein ID: WP_006318280.1
• Coordinates: 207824..208021 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS00890	202996..204267	+	1272	WP_006318285.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
Q5A_RS00895	204264..205463	+	1200	WP_006318284.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
Q5A_RS00900	205512..206075	-	564	WP_006318283.1	DcrB family lipoprotein	-
Q5A_RS00905	206156..206590	-	435	WP_006318282.1	GNAT family N-acetyltransferase	-
Q5A_RS00910	206633..207298	-	666	WP_006318281.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
Q5A_RS00915	207518..207763	+	246	WP_004950955.1	sulfurtransferase TusA	-
Q5A_RS00920	207824..208021	+	198	WP_006318280.1	hypothetical protein	Antitoxin
Q5A_RS00925	208022..208297	+	276	WP_006318279.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
Q5A_RS00930	208357..210672	-	2316	WP_065506795.1	zinc/cadmium/mercury/lead-transporting ATPase	-
Q5A_RS00935	211366..212829	+	1464	WP_006317219.1	serralysin family metalloprotease	-
Q5A_RS00940	212885..213262	+	378	WP_006317220.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10692.62 Da
• Isoelectric Point: 11.2606

>T63245 WP_006318279.1 NZ_CP015613:208022-208297 [Serratia inhibens PRI-2C]
MLVIEWSRSARQDLADILLFIANDNPRATRKMKVLISEAILPAAEHPHIFRRGRGDGMHEIIVHPNYLLIYQVVAERIRV
MRVLHARRRYP

Nucleotide

• Length: 276 bp

>T63245 NZ_CP015613:208022-208297 [Serratia inhibens PRI-2C]
ATGCTCGTCATCGAATGGAGTCGATCTGCTCGCCAGGACTTGGCGGATATACTGCTTTTCATTGCCAATGACAATCCTCG
GGCAACCAGAAAAATGAAGGTGTTAATTTCAGAAGCAATTCTTCCTGCCGCTGAACATCCTCATATTTTTCGCCGTGGCA
GGGGTGATGGCATGCACGAAATCATTGTTCATCCCAATTATCTTCTGATCTACCAAGTGGTTGCCGAACGTATCCGGGTG
ATGCGAGTCCTGCATGCACGCCGACGCTATCCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7550.62 Da
• Isoelectric Point: 4.4488

>AT63245 WP_006318280.1 NZ_CP015613:207824-208021 [Serratia inhibens PRI-2C]
MVILRSPVVSEYETQEQTEIYDRWFREKVREAMDDPLPGISHDEVMAEMDALIAVAEARKKAKQV

Nucleotide

• Length: 198 bp

>AT63245 NZ_CP015613:207824-208021 [Serratia inhibens PRI-2C]
ATGGTTATCTTACGCTCGCCCGTTGTCTCAGAATATGAGACACAAGAGCAGACGGAAATCTACGATCGCTGGTTTCGGGA
AAAGGTTCGGGAAGCCATGGATGATCCCCTGCCTGGCATTTCCCATGATGAGGTGATGGCCGAGATGGATGCTCTTATCG
CTGTAGCGGAAGCAAGGAAGAAAGCCAAACAGGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1B1KJS6