Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 144185..144821 Replicon chromosome
Accession NZ_CP015610
Organism Bacillus safensis strain U41

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag BSA41_RS00630 Protein ID WP_024425388.1
Coordinates 144471..144821 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag BSA41_RS00625 Protein ID WP_003214273.1
Coordinates 144185..144466 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSA41_RS00605 140326..140931 - 606 WP_041089200.1 rhomboid family intramembrane serine protease -
BSA41_RS00610 141026..141391 + 366 WP_075610922.1 holo-ACP synthase -
BSA41_RS00615 141552..142568 + 1017 WP_087975235.1 outer membrane lipoprotein carrier protein LolA -
BSA41_RS00620 142709..143890 + 1182 WP_075610923.1 alanine racemase -
BSA41_RS00625 144185..144466 + 282 WP_003214273.1 hypothetical protein Antitoxin
BSA41_RS00630 144471..144821 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BSA41_RS00635 144938..145768 + 831 WP_075610924.1 RsbT co-antagonist protein RsbRA -
BSA41_RS00640 145773..146141 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
BSA41_RS00645 146144..146545 + 402 WP_024425390.1 anti-sigma regulatory factor -
BSA41_RS00650 146556..147563 + 1008 WP_039176714.1 PP2C family protein-serine/threonine phosphatase -
BSA41_RS00655 147623..147952 + 330 WP_017358393.1 anti-sigma factor antagonist -
BSA41_RS00660 147949..148437 + 489 WP_075610925.1 anti-sigma B factor RsbW -
BSA41_RS00665 148403..149191 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
BSA41_RS00670 149191..149790 + 600 WP_041089211.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T63240 WP_024425388.1 NZ_CP015610:144471-144821 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T63240 NZ_CP015610:144471-144821 [Bacillus safensis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT63240 WP_003214273.1 NZ_CP015610:144185-144466 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT63240 NZ_CP015610:144185-144466 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References