Detailed information of TA system TA063216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1150435..1151051
• Replicon: chromosome
• Accession: NZ_CP015581
• Organism: Tatumella citrea strain ATCC 39140

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: A7K99_RS05490
• Protein ID: WP_087487657.1
• Coordinates: 1150435..1150653 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: A7K99_RS05495
• Protein ID: WP_087487658.1
• Coordinates: 1150671..1151051 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7K99_RS05460	1146127..1146996	-	870	WP_087487653.1	MFS transporter	-
A7K99_RS05470	1147926..1148789	-	864	WP_087487654.1	acyl-CoA thioesterase II	-
A7K99_RS05475	1148981..1149475	+	495	WP_087487655.1	YbaY family lipoprotein	-
A7K99_RS05480	1149502..1149816	-	315	WP_087487656.1	MGMT family protein	-
A7K99_RS05490	1150435..1150653	-	219	WP_087487657.1	hemolysin expression modulator Hha	Toxin
A7K99_RS05495	1150671..1151051	-	381	WP_087487658.1	Hha toxicity modulator TomB	Antitoxin
A7K99_RS05500	1152388..1152528	-	141	WP_087487659.1	type B 50S ribosomal protein L36	-
A7K99_RS05505	1152531..1152794	-	264	WP_087487660.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8587.94 Da
• Isoelectric Point: 8.8662

>T63216 WP_087487657.1 NZ_CP015581:c1150653-1150435 [Tatumella citrea]
MSSPTLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDEDLVVFYSAADHRLAELTMNKLYDKVPATVWKYVR

Nucleotide

• Length: 219 bp

>T63216 NZ_CP015581:c1150653-1150435 [Tatumella citrea]
ATGAGCAGCCCTACACTAACTAAAACAGATTATCTGATGCGTCTGAGACGTTGTCGGTCTATTGATACCCTTGAGCGGGT
AATCGAGAAGAATAAATATGAATTATCTGACGAAGATTTGGTGGTTTTTTATTCAGCCGCTGATCACCGTCTTGCTGAAC
TGACCATGAATAAATTGTATGACAAAGTTCCGGCAACCGTATGGAAGTATGTAAGGTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14739.47 Da
• Isoelectric Point: 4.5901

>AT63216 WP_087487658.1 NZ_CP015581:c1151051-1150671 [Tatumella citrea]
MDEYSPKRYDVAQLKFLCENLFDESIATLNVQQACWINDPASAENLQLHELIEHIAAFSILYKLKHSEDEQLIKQVDKYL
DDTFTLFSGYTVNKQDFSFWKTSSNQLFRLFFEASPCETNGHSFTH

Nucleotide

• Length: 381 bp

>AT63216 NZ_CP015581:c1151051-1150671 [Tatumella citrea]
ATGGATGAATACTCACCTAAACGGTATGATGTGGCGCAGTTGAAGTTTCTGTGTGAAAATCTGTTTGATGAAAGTATCGC
GACCCTCAACGTACAGCAGGCTTGCTGGATAAATGACCCTGCTTCAGCAGAAAACCTGCAACTGCACGAACTGATTGAAC
ACATTGCAGCTTTCAGTATTCTCTATAAATTAAAACATAGCGAAGACGAACAACTGATTAAACAGGTTGATAAATATCTT
GACGACACATTTACATTATTCAGTGGTTACACTGTAAATAAACAGGACTTTAGTTTCTGGAAAACATCGTCAAACCAGTT
ATTTAGATTATTTTTTGAGGCAAGTCCCTGTGAGACAAATGGACACAGCTTCACACATTAG