Detailed information of TA system TA063103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 2793227..2793677
• Replicon: chromosome
• Accession: NZ_CP015455
• Organism: Syntrophotalea acetylenica strain DSM 3246

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: A6070_RS13075
• Protein ID: WP_083558848.1
• Coordinates: 2793486..2793677 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L3GEG7
• Locus tag: A6070_RS13070
• Protein ID: WP_072286186.1
• Coordinates: 2793227..2793478 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6070_RS13045	2788928..2789653	-	726	WP_072286181.1	SIMPL domain-containing protein	-
A6070_RS13050	2789827..2790636	-	810	WP_072286182.1	HAD hydrolase-like protein	-
A6070_RS13055	2790873..2791565	-	693	WP_072286183.1	porin family protein	-
A6070_RS13060	2791628..2792392	-	765	WP_072286184.1	DNA alkylation repair protein	-
A6070_RS13065	2792467..2793060	-	594	WP_072286185.1	HD domain-containing protein	-
A6070_RS13070	2793227..2793478	+	252	WP_072286186.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A6070_RS13075	2793486..2793677	+	192	WP_083558848.1	Txe/YoeB family addiction module toxin	Toxin
A6070_RS13080	2793780..2794262	-	483	WP_072286187.1	hypothetical protein	-
A6070_RS13085	2794607..2795971	+	1365	WP_072286188.1	ISNCY family transposase	-
A6070_RS13090	2796062..2796430	-	369	WP_072286189.1	hypothetical protein	-
A6070_RS13095	2796557..2797180	-	624	WP_072286190.1	cold shock and DUF1294 domain-containing protein	-
A6070_RS13100	2797321..2797881	-	561	WP_072286191.1	hypothetical protein	-
A6070_RS13105	2798061..2798312	+	252	WP_072286192.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
A6070_RS13110	2798309..2798563	+	255	WP_072286193.1	Txe/YoeB family addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2787467..2816183	28716
	-	flank	IS/Tn	-	-	2794607..2795971	1364
	-	inside	Integron	-	-	2796557..2801696	5139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-63)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7559.73 Da
• Isoelectric Point: 10.0264

>T63103 WP_083558848.1 NZ_CP015455:2793486-2793677 [Syntrophotalea acetylenica]
IFRKRLNSLIRDIQRSPYEEPCKPEPLKHGLSGYWSRRITDEHRIVYKVGNDAIFIALAKYHY

Nucleotide

• Length: 192 bp

>T63103 NZ_CP015455:2793486-2793677 [Syntrophotalea acetylenica]
ATTTTCCGAAAACGCCTCAACTCTCTAATTCGGGATATTCAACGTTCCCCATACGAAGAGCCATGCAAACCCGAACCTCT
CAAACACGGCCTATCTGGCTATTGGTCACGCCGCATTACCGATGAGCACCGCATTGTCTATAAAGTCGGTAACGATGCTA
TTTTCATCGCTCTGGCAAAATACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9325.57 Da
• Isoelectric Point: 4.8481

>AT63103 WP_072286186.1 NZ_CP015455:2793227-2793478 [Syntrophotalea acetylenica]
MDAISYTKVRSNLAKTMEKVCEDHSPIIITRRNENSVVMISLEDYQALEETAYLLRSPKNARRLLESIAEPESGGGVARE
LSE

Nucleotide

• Length: 252 bp

>AT63103 NZ_CP015455:2793227-2793478 [Syntrophotalea acetylenica]
ATGGACGCTATTTCCTATACCAAAGTTCGCAGCAACTTGGCGAAGACCATGGAAAAAGTCTGTGAGGACCACTCCCCTAT
CATTATCACCCGCCGCAATGAAAACTCGGTTGTGATGATATCCCTTGAAGACTATCAGGCCCTTGAAGAAACAGCTTATC
TGCTGCGGAGCCCTAAAAACGCCCGGCGCCTCCTGGAATCGATTGCCGAACCTGAATCCGGCGGAGGGGTAGCGCGGGAA
TTGAGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1L3GEG7