Detailed information of TA system TA062908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 27668..28326
• Replicon: plasmid pAba3207b
• Accession: NZ_CP015366
• Organism: Acinetobacter baumannii strain 3207

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Aba3207_RS19465
• Protein ID: WP_000312250.1
• Coordinates: 27668..28027 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Aba3207_RS19470
• Protein ID: WP_001096429.1
• Coordinates: 28027..28326 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba3207_RS19435	23189..23503	-	315	WP_000708714.1	hypothetical protein	-
Aba3207_RS19440	24559..25317	-	759	WP_001053127.1	hypothetical protein	-
Aba3207_RS19445	25384..25767	-	384	WP_000654348.1	hypothetical protein	-
Aba3207_RS19450	25905..26603	-	699	WP_000873188.1	hypothetical protein	-
Aba3207_RS19455	26670..26852	-	183	WP_000373385.1	hypothetical protein	-
Aba3207_RS19460	26901..27467	-	567	WP_000710385.1	hypothetical protein	-
Aba3207_RS19465	27668..28027	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Aba3207_RS19470	28027..28326	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
Aba3207_RS19475	28864..29400	-	537	WP_000731978.1	hypothetical protein	-
Aba3207_RS19480	29450..30004	-	555	WP_000790084.1	hypothetical protein	-
Aba3207_RS19485	30024..30242	-	219	WP_001043201.1	hypothetical protein	-
Aba3207_RS19490	30282..30911	-	630	WP_000701003.1	hypothetical protein	-
Aba3207_RS19495	30928..31107	-	180	WP_000387630.1	hypothetical protein	-
Aba3207_RS19500	31083..31655	-	573	WP_000443897.1	hypothetical protein	-
Aba3207_RS19505	31660..31917	-	258	WP_000834290.1	hypothetical protein	-
Aba3207_RS19510	32022..33302	-	1281	WP_063558595.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..80546	80546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T62908 WP_000312250.1 NZ_CP015366:27668-28027 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T62908 NZ_CP015366:27668-28027 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT62908 WP_001096429.1 NZ_CP015366:28027-28326 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT62908 NZ_CP015366:28027-28326 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA