Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 9908..10493 Replicon plasmid pAba3207a
Accession NZ_CP015365
Organism Acinetobacter baumannii strain 3207

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Aba3207_RS19300 Protein ID WP_063558593.1
Coordinates 10173..10493 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Aba3207_RS19295 Protein ID WP_063558592.1
Coordinates 9908..10180 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba3207_RS19265 5440..6282 + 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
Aba3207_RS20195 6373..7125 + 753 Protein_8 IS1-like element ISAba3 family transposase -
Aba3207_RS19280 7253..8080 + 828 WP_000073658.1 AraC family transcriptional regulator -
Aba3207_RS19285 8130..8735 + 606 WP_000447788.1 LysE family translocator -
Aba3207_RS19295 9908..10180 - 273 WP_063558592.1 helix-turn-helix domain-containing protein Antitoxin
Aba3207_RS19300 10173..10493 - 321 WP_063558593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Aba3207_RS19305 10680..10877 - 198 WP_034583955.1 hypothetical protein -
Aba3207_RS19310 10944..11171 - 228 WP_004745640.1 hypothetical protein -
Aba3207_RS19315 11269..11484 - 216 WP_000071892.1 cold-shock protein -
Aba3207_RS20705 11815..11991 - 177 WP_162885653.1 hypothetical protein -
Aba3207_RS19320 11988..12359 - 372 WP_000504220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..13478 13478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12139.90 Da        Isoelectric Point: 6.9790

>T62907 WP_063558593.1 NZ_CP015365:c10493-10173 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYSQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T62907 NZ_CP015365:c10493-10173 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATAGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10121.55 Da        Isoelectric Point: 7.2045

>AT62907 WP_063558592.1 NZ_CP015365:c10180-9908 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPNLI

Download         Length: 273 bp

>AT62907 NZ_CP015365:c10180-9908 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATTAAAGAAGCTGGGGCTATCAAACGTAATGAGATAAAGGCCAG
TCGAGTCACAGAGCTTGAGTTACCGGACATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCAGAGTTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTACAGAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTCTAGATGCTCATCCAAATTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References