Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4669335..4670002 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A4R40_RS20490 Protein ID WP_109791828.1
Coordinates 4669335..4669658 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A4R40_RS20495 Protein ID WP_011148114.1
Coordinates 4669706..4670002 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS20470 4665712..4667556 + 1845 WP_109791827.1 RNA polymerase sigma factor RpoD -
A4R40_RS20485 4668379..4668951 - 573 WP_082302905.1 Bro-N domain-containing protein -
A4R40_RS20490 4669335..4669658 + 324 WP_109791828.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS20495 4669706..4670002 + 297 WP_011148114.1 helix-turn-helix domain-containing protein Antitoxin
A4R40_RS25630 4670428..4670628 + 201 WP_125026254.1 hypothetical protein -
A4R40_RS20500 4671016..4671945 - 930 WP_109791829.1 hypothetical protein -
A4R40_RS20505 4672066..4673010 - 945 WP_109791830.1 class I SAM-dependent methyltransferase -
A4R40_RS20510 4673148..4673681 - 534 WP_109791831.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(34-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-92)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12522.63 Da        Isoelectric Point: 10.1456

>T62859 WP_109791828.1 NZ_CP015281:4669335-4669658 [Photorhabdus laumondii subsp. laumondii]
MEYLVFIETPVFSKERAELLTDDEFRLLQEHLLKNHEQGSTISATGGCKKIRWQRERIGKRGGVRIIYYAITKTGRLYLL
LIYPKNKKDDLTPKEKEVLKAISNKLQ

Download         Length: 324 bp

>T62859 NZ_CP015281:4669335-4669658 [Photorhabdus laumondii subsp. laumondii]
ATGGAATATCTGGTTTTTATTGAAACTCCCGTATTTAGTAAAGAACGAGCAGAACTGTTAACCGATGATGAATTTAGGCT
ATTACAGGAGCACTTACTAAAGAATCACGAGCAGGGTAGTACCATCAGCGCTACTGGAGGATGTAAAAAGATTCGTTGGC
AGCGAGAAAGGATAGGAAAACGTGGCGGAGTAAGAATTATCTACTATGCCATAACCAAAACTGGGAGGCTCTATCTCCTT
TTGATTTACCCTAAAAATAAAAAAGATGACTTAACTCCAAAAGAAAAAGAGGTACTTAAAGCCATCAGTAACAAATTACA
GTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11269.92 Da        Isoelectric Point: 6.2274

>AT62859 WP_011148114.1 NZ_CP015281:4669706-4670002 [Photorhabdus laumondii subsp. laumondii]
MDKRLFNDLVESMNQMVAIEKGELSVFDENIHYHRLPDVKNLRETFGLKQSEFAEAVGVSTSLIQSWEQHRRIPSGSSLK
LLKMLERNPALINELSTL

Download         Length: 297 bp

>AT62859 NZ_CP015281:4669706-4670002 [Photorhabdus laumondii subsp. laumondii]
ATGGACAAAAGACTTTTTAACGATCTGGTTGAAAGCATGAATCAGATGGTAGCAATTGAAAAAGGCGAACTTTCTGTTTT
TGATGAAAATATCCATTACCATCGCCTGCCTGATGTAAAAAACTTACGTGAAACCTTTGGCTTAAAACAAAGTGAATTTG
CCGAAGCTGTTGGCGTTTCTACATCTCTAATTCAAAGCTGGGAACAGCACCGCCGCATTCCTTCTGGTTCATCACTGAAA
CTACTTAAGATGCTTGAACGTAATCCTGCGCTTATTAATGAATTAAGCACACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References