Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4565546..4566345 | Replicon | chromosome |
| Accession | NZ_CP015281 | ||
| Organism | Photorhabdus laumondii subsp. laumondii strain DSPV002N | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q7N0J4 |
| Locus tag | A4R40_RS20015 | Protein ID | WP_011148028.1 |
| Coordinates | 4565821..4566345 (+) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | Q7N0J5 |
| Locus tag | A4R40_RS20010 | Protein ID | WP_011148027.1 |
| Coordinates | 4565546..4565824 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A4R40_RS19995 | 4561766..4562044 | + | 279 | WP_011148023.1 | exodeoxyribonuclease VII small subunit | - |
| A4R40_RS20000 | 4562049..4562966 | + | 918 | WP_011148024.1 | (2E,6E)-farnesyl diphosphate synthase | - |
| A4R40_RS20005 | 4563029..4564894 | + | 1866 | WP_011148025.1 | 1-deoxy-D-xylulose-5-phosphate synthase | - |
| A4R40_RS20010 | 4565546..4565824 | + | 279 | WP_011148027.1 | DUF1778 domain-containing protein | Antitoxin |
| A4R40_RS20015 | 4565821..4566345 | + | 525 | WP_011148028.1 | N-acetyltransferase | Toxin |
| A4R40_RS20020 | 4566486..4567255 | + | 770 | Protein_3831 | IS982 family transposase | - |
| A4R40_RS20025 | 4567421..4567743 | - | 323 | Protein_3832 | type II toxin-antitoxin system YafQ family toxin | - |
| A4R40_RS20030 | 4567715..4567987 | - | 273 | WP_011148029.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| A4R40_RS20040 | 4568267..4568758 | - | 492 | WP_011148030.1 | phosphatidylglycerophosphatase A | - |
| A4R40_RS20045 | 4568751..4569740 | - | 990 | WP_011148031.1 | thiamine-phosphate kinase | - |
| A4R40_RS20050 | 4569841..4570257 | - | 417 | WP_011148032.1 | transcription antitermination factor NusB | - |
| A4R40_RS20055 | 4570284..4570754 | - | 471 | WP_011148033.1 | 6,7-dimethyl-8-ribityllumazine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 18864.82 Da Isoelectric Point: 9.3787
>T62856 WP_011148028.1 NZ_CP015281:4565821-4566345 [Photorhabdus laumondii subsp. laumondii]
MMLPIWHEEPIGKHHDRGAFDCGDEALNQFLHRHARQSHEKGGAKTYLAVSKNNGTVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAIDLSVQSQGLGGQLLLAAGRRCLLVAAQAGGVALLIDAKNERVAEWYASYGAIPLLDAHLSLLLP
FKTIHAALVTAGKL
MMLPIWHEEPIGKHHDRGAFDCGDEALNQFLHRHARQSHEKGGAKTYLAVSKNNGTVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAIDLSVQSQGLGGQLLLAAGRRCLLVAAQAGGVALLIDAKNERVAEWYASYGAIPLLDAHLSLLLP
FKTIHAALVTAGKL
Download Length: 525 bp
>T62856 NZ_CP015281:4565821-4566345 [Photorhabdus laumondii subsp. laumondii]
ATGATGCTACCAATCTGGCACGAAGAACCTATAGGCAAACATCATGATCGTGGTGCTTTTGACTGTGGTGATGAGGCGTT
GAATCAGTTTTTACATCGCCATGCAAGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCAGTTAGCAAGAACA
ATGGAACGGTATTAGGTTACTACAGTCTAAGTCCCGCTTCTATTGCTTATGAACGTGCACCGGAAGTGATTAAACGTGGT
CTGGCTCGACATGAAGTGCCAGTATTTCGGCTTGGCCGTCTGGCTATAGATCTTTCAGTACAGAGTCAAGGACTCGGTGG
TCAGTTGTTGCTAGCCGCTGGTCGGCGCTGTTTATTGGTGGCCGCACAGGCTGGCGGGGTTGCATTGCTGATTGATGCCA
AGAATGAGCGTGTTGCCGAGTGGTACGCCAGCTATGGTGCTATTCCGCTATTAGATGCCCACCTATCTTTGCTGTTACCA
TTCAAAACAATACATGCAGCTCTAGTCACTGCGGGGAAGCTTTAA
ATGATGCTACCAATCTGGCACGAAGAACCTATAGGCAAACATCATGATCGTGGTGCTTTTGACTGTGGTGATGAGGCGTT
GAATCAGTTTTTACATCGCCATGCAAGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCAGTTAGCAAGAACA
ATGGAACGGTATTAGGTTACTACAGTCTAAGTCCCGCTTCTATTGCTTATGAACGTGCACCGGAAGTGATTAAACGTGGT
CTGGCTCGACATGAAGTGCCAGTATTTCGGCTTGGCCGTCTGGCTATAGATCTTTCAGTACAGAGTCAAGGACTCGGTGG
TCAGTTGTTGCTAGCCGCTGGTCGGCGCTGTTTATTGGTGGCCGCACAGGCTGGCGGGGTTGCATTGCTGATTGATGCCA
AGAATGAGCGTGTTGCCGAGTGGTACGCCAGCTATGGTGCTATTCCGCTATTAGATGCCCACCTATCTTTGCTGTTACCA
TTCAAAACAATACATGCAGCTCTAGTCACTGCGGGGAAGCTTTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10343.93 Da Isoelectric Point: 5.1133
>AT62856 WP_011148027.1 NZ_CP015281:4565546-4565824 [Photorhabdus laumondii subsp. laumondii]
MPQIPVETNDRMSLRIASEEKSLLMRAAALQHTNLTEFVLRNVMPAARKVIDENERLELTERDSLHVLDLLDNPPAPNDK
LLAAAFALPKQS
MPQIPVETNDRMSLRIASEEKSLLMRAAALQHTNLTEFVLRNVMPAARKVIDENERLELTERDSLHVLDLLDNPPAPNDK
LLAAAFALPKQS
Download Length: 279 bp
>AT62856 NZ_CP015281:4565546-4565824 [Photorhabdus laumondii subsp. laumondii]
ATGCCTCAGATCCCAGTAGAAACTAACGACCGAATGTCGCTACGTATTGCCTCAGAAGAAAAGTCGCTGTTGATGCGTGC
AGCCGCTTTACAACATACCAACTTGACTGAGTTCGTGCTCCGCAATGTGATGCCAGCAGCACGGAAAGTTATCGACGAGA
ACGAACGGCTGGAGCTGACCGAAAGAGATAGTTTGCATGTTCTGGATCTTTTGGATAACCCACCGGCACCCAATGATAAA
TTGTTGGCCGCAGCATTTGCCTTGCCGAAACAATCATGA
ATGCCTCAGATCCCAGTAGAAACTAACGACCGAATGTCGCTACGTATTGCCTCAGAAGAAAAGTCGCTGTTGATGCGTGC
AGCCGCTTTACAACATACCAACTTGACTGAGTTCGTGCTCCGCAATGTGATGCCAGCAGCACGGAAAGTTATCGACGAGA
ACGAACGGCTGGAGCTGACCGAAAGAGATAGTTTGCATGTTCTGGATCTTTTGGATAACCCACCGGCACCCAATGATAAA
TTGTTGGCCGCAGCATTTGCCTTGCCGAAACAATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JMG1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JLN0 |