Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 190549..191300 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name ataT Uniprot ID Q7N9X2
Locus tag A4R40_RS00925 Protein ID WP_011144581.1
Coordinates 190549..191037 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q7N9X1
Locus tag A4R40_RS00930 Protein ID WP_011144582.1
Coordinates 191028..191300 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS00905 185976..187457 + 1482 WP_011144577.1 fructuronate reductase -
A4R40_RS00910 187454..188878 + 1425 WP_011144578.1 glucuronate isomerase -
A4R40_RS00915 188875..189819 + 945 WP_011144579.1 sugar kinase -
A4R40_RS00920 189837..190466 + 630 WP_041379857.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
A4R40_RS00925 190549..191037 - 489 WP_011144581.1 GNAT family N-acetyltransferase Toxin
A4R40_RS00930 191028..191300 - 273 WP_011144582.1 DUF1778 domain-containing protein Antitoxin
A4R40_RS00935 192436..193941 + 1506 WP_011144584.1 asparagine synthase -
A4R40_RS00940 193944..194693 + 750 WP_011144585.1 enoyl-CoA hydratase/isomerase family protein -
A4R40_RS00945 194707..195528 + 822 WP_011144586.1 TauD/TfdA family dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-83)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17983.77 Da        Isoelectric Point: 8.2629

>T62833 WP_011144581.1 NZ_CP015281:c191037-190549 [Photorhabdus laumondii subsp. laumondii]
VGISTPEILTAEHNINDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DPIPVVLLGRLAVDVEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHALDESARTFYTRLGFVQSPLEPYTLMLPLGK
QK

Download         Length: 489 bp

>T62833 NZ_CP015281:c191037-190549 [Photorhabdus laumondii subsp. laumondii]
GTGGGAATAAGCACACCTGAAATATTAACGGCTGAACATAATATAAATGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCTTTAAAAAATAATAAGCTCGGCGCGAGCCGCACATTTGTTATTTGCAAGGAAGGCACAAAAG
ACGTTATCGGTTATTATTGTCTAAGCGCCGGTTCAATTAATCATATTGAATCTACACCATCGCTTAAACGCAATATGCCA
GATCCTATCCCTGTAGTGCTTCTTGGCCGTCTGGCTGTCGATGTGGAATATCAGGGGAAGAAGCTCGGGGCATTGCTTCT
CCAAGATGCTTGGAAGCGTGTCGCCAGCACAGCAGAACAGGTGGGCATTTCAGCTATAATCGTCCACGCACTTGATGAGA
GCGCTCGAACGTTCTATACGCGTCTTGGCTTCGTCCAGTCACCGTTGGAGCCATACACGCTGATGCTTCCATTAGGCAAA
CAGAAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10587.15 Da        Isoelectric Point: 6.7179

>AT62833 WP_011144582.1 NZ_CP015281:c191300-191028 [Photorhabdus laumondii subsp. laumondii]
MRTQPKETPINIRAKAFQRELIDHAANLLSKTRTDFILDAACRAAEDAILDQRHFFVNDEKYHMFMQMLEQPLSDNEGFK
KLMGYKAPWE

Download         Length: 273 bp

>AT62833 NZ_CP015281:c191300-191028 [Photorhabdus laumondii subsp. laumondii]
ATGAGAACACAACCTAAAGAAACCCCGATCAACATCCGGGCGAAAGCCTTCCAGCGGGAGCTTATTGACCATGCAGCAAA
CCTGCTCTCAAAGACCCGAACTGATTTCATCTTGGACGCTGCCTGCCGCGCAGCCGAAGATGCCATACTCGATCAGCGCC
ACTTTTTCGTTAACGACGAAAAATACCATATGTTCATGCAGATGCTGGAGCAACCGCTTTCTGATAATGAAGGTTTTAAA
AAACTGATGGGATATAAAGCACCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JKT6

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JKU1

References