Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3836883..3837715 | Replicon | chromosome |
| Accession | NZ_CP015229 | ||
| Organism | Escherichia coli strain 06-00048 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A193LX83 |
| Locus tag | GJ11_RS21040 | Protein ID | WP_065227648.1 |
| Coordinates | 3837341..3837715 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A193LX96 |
| Locus tag | GJ11_RS21035 | Protein ID | WP_065228272.1 |
| Coordinates | 3836883..3837251 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJ11_RS21005 | 3833761..3834216 | + | 456 | WP_065227643.1 | hypothetical protein | - |
| GJ11_RS21010 | 3834295..3834528 | + | 234 | WP_065227644.1 | DUF905 family protein | - |
| GJ11_RS21015 | 3834628..3835446 | + | 819 | WP_065227645.1 | DUF945 domain-containing protein | - |
| GJ11_RS21020 | 3835537..3836022 | + | 486 | WP_065227646.1 | antirestriction protein | - |
| GJ11_RS21025 | 3836038..3836514 | + | 477 | WP_065227647.1 | RadC family protein | - |
| GJ11_RS21030 | 3836583..3836804 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| GJ11_RS21035 | 3836883..3837251 | + | 369 | WP_065228272.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GJ11_RS21040 | 3837341..3837715 | + | 375 | WP_065227648.1 | TA system toxin CbtA family protein | Toxin |
| GJ11_RS21045 | 3837712..3838200 | + | 489 | WP_065227649.1 | hypothetical protein | - |
| GJ11_RS21050 | 3838212..3838409 | + | 198 | WP_001374283.1 | DUF957 domain-containing protein | - |
| GJ11_RS21055 | 3838494..3839336 | + | 843 | WP_065227650.1 | DUF4942 domain-containing protein | - |
| GJ11_RS21060 | 3839616..3840152 | - | 537 | WP_065227651.1 | GspM family type II secretion system protein YghD | - |
| GJ11_RS21065 | 3840157..3841332 | - | 1176 | WP_065227652.1 | type II secretion system protein GspL | - |
| GJ11_RS21070 | 3841329..3842306 | - | 978 | WP_065227653.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | faeJ / faeI / faeH / faeF / faeE / faeD / faeC / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3781081..3914936 | 133855 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14134.12 Da Isoelectric Point: 7.8045
>T62696 WP_065227648.1 NZ_CP015229:3837341-3837715 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NTCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NTCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T62696 NZ_CP015229:3837341-3837715 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AACACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACCCTTGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AACACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACCCTTGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13699.42 Da Isoelectric Point: 6.3159
>AT62696 WP_065228272.1 NZ_CP015229:3836883-3837251 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCDYVYLAVYPTPETKK
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCDYVYLAVYPTPETKK
Download Length: 369 bp
>AT62696 NZ_CP015229:3836883-3837251 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A193LX83 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A193LX96 |