Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 2262273..2263705 Replicon chromosome
Accession NZ_CP015196
Organism Streptococcus marmotae strain HTS5

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag A4H00_RS11060 Protein ID WP_067091156.1
Coordinates 2262860..2263705 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag A4H00_RS11055 Protein ID WP_067091151.1
Coordinates 2262273..2262863 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4H00_RS11040 2257886..2258572 - 687 WP_067091146.1 ribonuclease III -
A4H00_RS11045 2258703..2259819 - 1117 Protein_2137 ISAs1 family transposase -
A4H00_RS11050 2259918..2262079 - 2162 Protein_2138 glucan-binding protein -
A4H00_RS11055 2262273..2262863 + 591 WP_067091151.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
A4H00_RS11060 2262860..2263705 + 846 WP_067091156.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A4H00_RS11590 2263805..2265694 - 1890 Protein_2141 CHAP domain-containing protein -
A4H00_RS12125 2265701..2266900 - 1200 Protein_2142 type IV secretory system conjugative DNA transfer family protein -
A4H00_RS11070 2266900..2267388 - 489 WP_067091160.1 hypothetical protein -
A4H00_RS11075 2267472..2268053 - 582 WP_067091163.1 CPBP family intramembrane metalloprotease -
A4H00_RS11080 2268056..2268289 - 234 WP_067091167.1 hypothetical protein -
A4H00_RS11085 2268299..2268682 - 384 WP_067091170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2258703..2259464 761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-266)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-51)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32486.82 Da        Isoelectric Point: 5.0082

>T62611 WP_067091156.1 NZ_CP015196:2262860-2263705 [Streptococcus marmotae]
MNKAKLTALCHKISKQTGLTFNSVMTYYFLEIILKKLSQSSYSNYYIFKGGFLLSNVIGVESRSTVDIDFLFHKQTLSEE
NVQQQLEEILTDSKDDIQFSIQSITTIKESDDYGGYRATILCQLENIKQIIHLDIATGDVVTPQPVTYNYKAIFDDENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKNDIDFSQLKIACQRTFSYRETELDFNNIIQLLETFKSDP
IQEQQWQNYSKKYNYTKGISFSDILNEIISLVSTLTSTSNG

Download         Length: 846 bp

>T62611 NZ_CP015196:2262860-2263705 [Streptococcus marmotae]
ATGAATAAAGCAAAATTAACAGCACTCTGCCATAAAATTTCTAAACAAACAGGCCTAACTTTTAATTCAGTAATGACCTA
CTACTTTCTTGAAATCATTTTGAAAAAGCTAAGTCAAAGTTCTTATTCGAATTACTATATTTTTAAGGGTGGATTTTTAC
TTTCAAATGTCATAGGAGTTGAATCTCGTAGTACGGTGGATATTGACTTTTTGTTTCATAAACAAACTCTATCAGAAGAA
AATGTTCAACAACAACTTGAAGAAATTTTAACCGATTCGAAAGATGATATTCAATTTTCAATTCAATCCATTACAACGAT
TAAAGAAAGCGATGATTACGGTGGTTACCGAGCAACCATTTTATGTCAACTGGAAAACATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGATGTTGTAACGCCACAGCCCGTTACTTACAACTATAAAGCTATTTTTGATGATGAAAATTTCCCC
ATCATTGCTTATACGATTGAAACTATTTTAGCTGAAAAATTACAAACCATTTACTCAAGAAATTTCTTGAACAGTCGCAG
TAAAGATTTTTACGATGTCTATATCCTTTCTAAGTTAAAGAAAAATGACATTGACTTTTCACAATTAAAAATTGCTTGTC
AAAGAACCTTTTCCTATCGTGAAACCGAACTCGACTTTAATAACATCATTCAACTTTTAGAAACATTCAAATCTGACCCT
ATTCAAGAGCAACAATGGCAAAACTATTCAAAAAAATATAATTATACAAAAGGTATTTCCTTTTCAGATATCCTCAATGA
GATTATCAGTTTAGTAAGTACCCTAACTTCTACAAGTAATGGTTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23091.51 Da        Isoelectric Point: 7.2351

>AT62611 WP_067091151.1 NZ_CP015196:2262273-2262863 [Streptococcus marmotae]
MSKKELLLNYLDNHNGIITYRDCKKMGIPTIYLTRLEDEGVIFRVEKGIYLSSSGNYDEYYFFQYRYPRTVFSHISALYL
QGLTDEIPQYFEVTVPKDYRFRNTPLNLNVHTVSKDIVTLGVTSVKTPMGNTVNVYDFERILCDFILNRDNIDTELFVKT
LQTYSNFPKKNLTKLYEYAQKLNILDEVKRTLEVLL

Download         Length: 591 bp

>AT62611 NZ_CP015196:2262273-2262863 [Streptococcus marmotae]
ATGTCAAAAAAAGAACTGTTACTTAACTACTTAGACAATCACAATGGCATAATTACCTATAGAGATTGTAAAAAAATGGG
TATTCCAACCATATATCTGACAAGACTAGAAGATGAAGGAGTTATCTTTAGGGTCGAAAAAGGTATCTATCTGTCCTCTA
GCGGAAATTATGATGAATACTATTTCTTTCAGTATCGCTATCCCAGAACTGTTTTTTCTCATATCTCTGCTCTTTATCTA
CAAGGACTTACAGATGAAATTCCTCAATATTTTGAAGTAACAGTTCCAAAGGACTACCGTTTTAGAAATACTCCGTTAAA
TCTAAATGTCCATACTGTTTCTAAAGACATTGTCACCCTTGGAGTTACCAGTGTAAAAACCCCTATGGGAAATACCGTTA
ATGTTTATGATTTTGAACGTATTCTATGTGATTTTATCCTCAACCGAGATAACATTGATACTGAGCTCTTTGTCAAAACA
CTTCAAACTTATAGCAACTTCCCTAAAAAAAATCTCACAAAACTCTATGAATATGCCCAAAAACTAAATATCTTAGATGA
AGTTAAACGAACCTTGGAGGTACTCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References