Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 116230..116830 Replicon chromosome
Accession NZ_CP015101
Organism Thermococcus barossii strain SHCK-94

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L01_RS00630 Protein ID WP_088863996.1
Coordinates 116438..116830 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L01_RS00625 Protein ID WP_088863995.1
Coordinates 116230..116451 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L01_RS00610 (A3L01_00620) 111752..113611 - 1860 WP_088863992.1 ATP-binding protein -
A3L01_RS00615 (A3L01_00625) 113608..115683 - 2076 WP_088863993.1 DNA double-strand break repair nuclease NurA -
A3L01_RS00620 (A3L01_00630) 115670..116101 - 432 WP_157723203.1 hypothetical protein -
A3L01_RS00625 (A3L01_00635) 116230..116451 + 222 WP_088863995.1 hypothetical protein Antitoxin
A3L01_RS00630 (A3L01_00640) 116438..116830 + 393 WP_088863996.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L01_RS00635 (A3L01_00645) 116823..117530 - 708 WP_088863997.1 HAD family hydrolase -
A3L01_RS00640 (A3L01_00650) 117571..118608 - 1038 WP_088863998.1 DUF3226 domain-containing protein -
A3L01_RS00645 (A3L01_00655) 118609..119148 - 540 WP_232460726.1 DUF2391 family protein -
A3L01_RS00650 (A3L01_00660) 119213..120682 + 1470 WP_088863999.1 S-layer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-122)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14514.82 Da        Isoelectric Point: 5.7696

>T62344 WP_088863996.1 NZ_CP015101:116438-116830 [Thermococcus barossii]
VIVVDASALVKVVLQEPGWEKVPVEPSVATLDYALVEGMNAIWKAVRRKELTLEQGKIKITVLKTLGSSLTLFEAGNFFE
RGLEIALKENITIYDALYIALAEALNAEFHTADERQYHAAQNYVRAKLVR

Download         Length: 393 bp

>T62344 NZ_CP015101:116438-116830 [Thermococcus barossii]
GTGATAGTCGTTGATGCTTCAGCCCTTGTAAAGGTCGTCCTTCAGGAGCCCGGCTGGGAAAAGGTTCCAGTGGAGCCCAG
CGTGGCGACCCTCGACTACGCGCTCGTCGAAGGCATGAACGCCATCTGGAAGGCGGTGCGGCGAAAAGAATTGACCTTGG
AACAGGGAAAGATCAAGATAACCGTGCTCAAGACATTGGGGAGTTCATTAACCCTCTTCGAGGCCGGGAACTTCTTTGAG
CGCGGCCTTGAGATAGCGCTGAAAGAAAACATAACCATCTACGATGCCCTCTACATAGCCCTCGCTGAAGCCCTCAACGC
TGAGTTCCACACCGCCGACGAGAGGCAGTACCATGCGGCTCAAAATTATGTAAGGGCAAAGCTGGTCAGGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8670.97 Da        Isoelectric Point: 10.7362

>AT62344 WP_088863995.1 NZ_CP015101:116230-116451 [Thermococcus barossii]
MAIVTVRVPDELKLKMKELNINWSEEIREFIRRRIDEEERRRKIREALELAKASGSVSRGFAAKSVREDRDSR

Download         Length: 222 bp

>AT62344 NZ_CP015101:116230-116451 [Thermococcus barossii]
ATGGCCATCGTCACCGTCCGCGTCCCCGACGAGCTGAAGCTCAAGATGAAGGAGCTGAACATCAACTGGAGCGAGGAGAT
AAGGGAGTTCATAAGAAGGCGCATAGACGAGGAGGAGCGGAGACGAAAGATACGGGAAGCTCTGGAGCTTGCAAAAGCAA
GCGGGAGCGTGAGCAGGGGCTTTGCAGCGAAGTCCGTGAGGGAGGACCGTGATAGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References