Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 636188..636825 Replicon chromosome
Accession NZ_CP015002
Organism Pseudomonas aeruginosa strain PA8281

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PA8281_RS02950 Protein ID WP_019725766.1
Coordinates 636188..636370 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PA8281_RS02955 Protein ID WP_019725767.1
Coordinates 636403..636825 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA8281_RS33550 632068..632356 - 289 Protein_582 DDE-type integrase/transposase/recombinase -
PA8281_RS32400 632422..633798 + 1377 WP_076611796.1 IS30-like element ISPa37 family transposase -
PA8281_RS32405 633806..634682 - 877 Protein_584 IS3 family transposase -
PA8281_RS02945 634747..635611 - 865 Protein_585 site-specific integrase -
PA8281_RS02950 636188..636370 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
PA8281_RS02955 636403..636825 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PA8281_RS02960 637071..638042 - 972 WP_025982283.1 hypothetical protein -
PA8281_RS02965 638027..638719 - 693 WP_019725770.1 hypothetical protein -
PA8281_RS02970 638716..639258 - 543 WP_025982284.1 hypothetical protein -
PA8281_RS02975 639255..640178 - 924 WP_019725772.1 hypothetical protein -
PA8281_RS02980 640175..640651 - 477 WP_019725773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 623819..684676 60857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T61985 WP_019725766.1 NZ_CP015002:636188-636370 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

>T61985 NZ_CP015002:636188-636370 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATTTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT61985 WP_019725767.1 NZ_CP015002:636403-636825 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp

>AT61985 NZ_CP015002:636403-636825 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References