Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii(toxin)
Location 352169..353798 Replicon chromosome
Accession NZ_CP014855
Organism Thermococcus gorgonarius strain W-12

Toxin (Protein)


Gene name PygT Uniprot ID -
Locus tag A3K92_RS02015 Protein ID WP_088884681.1
Coordinates 352782..353798 (+) Length 339 a.a.

Antitoxin (Protein)


Gene name PygA Uniprot ID -
Locus tag A3K92_RS02010 Protein ID WP_088884680.1
Coordinates 352169..352792 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3K92_RS01990 (A3K92_01990) 348647..349195 + 549 WP_088884676.1 hypothetical protein -
A3K92_RS01995 (A3K92_01995) 349215..350291 + 1077 WP_157722408.1 hypothetical protein -
A3K92_RS02000 (A3K92_02000) 350296..351243 + 948 WP_088884678.1 hypothetical protein -
A3K92_RS02005 (A3K92_02005) 351334..352071 + 738 WP_088884679.1 hypothetical protein -
A3K92_RS02010 (A3K92_02010) 352169..352792 + 624 WP_088884680.1 hypothetical protein Antitoxin
A3K92_RS02015 (A3K92_02015) 352782..353798 + 1017 WP_088884681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
A3K92_RS02020 (A3K92_02020) 353791..357165 + 3375 WP_088884682.1 helicase-related protein -
A3K92_RS02025 (A3K92_02025) 357226..357672 + 447 WP_198361963.1 DUF365 domain-containing protein -
A3K92_RS02030 (A3K92_02030) 357726..358739 + 1014 WP_088884683.1 type I restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(48-278)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 339 a.a.        Molecular weight: 40156.20 Da        Isoelectric Point: 8.2044

>T61843 WP_088884681.1 NZ_CP014855:352782-353798 [Thermococcus gorgonarius]
MPDESLLMEIRKNERRGFARFVSRKTKIKSVDLVEWDYIIHTILKELERDPLFKENYVFKGGTCLVKCHLGYYRFSRDLD
FAYRQGDELREMSRSRLKKFLNEETGRIAEILKCVARDLGLEFQYNSHSDFNNHRYFSFLLGPGWFREIILYSPLREKIK
IEVNYAERLAFRPKTLKAHTLLSWKRVELTPKEYERYVEFLGNYYPVSLVAYSDREILVEKVRALLTRKEFKLRDLYDLY
KLHQRGLKVSHYRNEIADKVRTYLALSSTASQNLGSSIEALQKGKFLVDIEPEIDRDIGLIVEPFSKEEFLNFVEELRFE
LGNLIDELKDLIEVETNG

Download         Length: 1017 bp

>T61843 NZ_CP014855:352782-353798 [Thermococcus gorgonarius]
ATGCCCGATGAGTCCCTTCTCATGGAGATTCGGAAGAACGAAAGAAGGGGTTTCGCCAGGTTTGTATCGCGAAAAACGAA
GATAAAATCCGTAGACCTCGTGGAGTGGGACTACATAATCCACACAATCCTCAAGGAGCTTGAGAGGGATCCTCTCTTCA
AGGAGAACTACGTCTTCAAGGGAGGAACATGCCTTGTTAAATGCCACCTCGGTTATTATCGCTTCAGCAGGGATCTCGAC
TTCGCGTACCGGCAGGGCGATGAGCTTAGAGAGATGAGCCGAAGCAGGCTGAAAAAATTCCTGAACGAAGAAACGGGCAG
AATTGCGGAGATCCTGAAGTGCGTGGCCAGGGATCTGGGCCTTGAATTCCAATACAATAGTCACAGCGACTTCAACAACC
ACAGATATTTTAGCTTTCTCCTTGGCCCCGGCTGGTTTAGGGAAATAATACTCTACTCTCCCTTGAGGGAGAAGATAAAA
ATAGAGGTAAATTACGCTGAAAGACTAGCATTCAGGCCAAAGACTCTAAAGGCCCACACCCTCCTGTCATGGAAGCGTGT
TGAACTCACACCAAAGGAGTACGAGAGGTACGTTGAGTTTCTCGGCAACTATTATCCCGTTTCCCTAGTGGCTTATTCTG
ATAGGGAAATTTTAGTTGAAAAAGTTAGGGCCCTTCTAACAAGAAAAGAGTTCAAGCTCAGGGATCTCTACGACCTTTAC
AAGCTTCACCAGAGGGGTCTCAAGGTAAGCCATTACAGGAATGAGATAGCGGACAAGGTCAGGACTTATCTCGCATTAAG
TTCCACGGCATCTCAGAACTTGGGAAGCTCGATAGAGGCTCTACAAAAGGGGAAGTTCCTTGTGGATATCGAACCAGAGA
TAGATCGGGATATTGGTCTCATCGTTGAACCCTTCTCAAAGGAAGAGTTTTTGAACTTCGTTGAGGAGTTACGTTTTGAA
CTTGGCAATCTCATTGACGAATTGAAGGACTTGATTGAGGTGGAAACCAATGGCTGA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 24256.21 Da        Isoelectric Point: 10.1907

>AT61843 WP_088884680.1 NZ_CP014855:352169-352792 [Thermococcus gorgonarius]
MKPIIQFLLAEFGGKAITREELERLASSFNEDLDYLVNYLIQYGYVIRILRGLYYVKTPVEFSTGGSPSIYRLLALGMDR
LTRNWYFGLFTALILNGLTHETYTTVFVINDRIARPKPITVNGISVRIIRSRKNIFDFGIVVRDSLRFSDLEKTLLDFLY
FANYGTIPKSLALRIWEEYQDRASKDKLQKYLRRYPRSIRKVVENAR

Download         Length: 624 bp

>AT61843 NZ_CP014855:352169-352792 [Thermococcus gorgonarius]
ATGAAGCCTATCATTCAGTTCCTGCTTGCAGAGTTTGGGGGGAAGGCGATAACCCGCGAGGAACTGGAGAGACTGGCCTC
CAGCTTCAATGAGGACCTTGACTATCTGGTTAACTATCTGATTCAGTACGGTTACGTCATTCGCATATTACGGGGCCTCT
ACTACGTGAAAACACCTGTTGAGTTTTCAACAGGAGGTTCTCCTTCGATCTACCGACTTTTGGCTCTGGGAATGGATAGA
CTAACGAGGAATTGGTACTTCGGCCTCTTCACGGCCCTGATTCTGAATGGCCTCACCCACGAAACCTACACGACGGTCTT
CGTGATAAATGACAGAATAGCGAGGCCAAAGCCAATCACCGTGAATGGAATCTCTGTTAGAATAATCCGGAGCAGGAAGA
ACATTTTTGACTTTGGAATCGTTGTCAGAGACTCCCTCAGGTTTTCAGACCTTGAGAAGACCCTCCTGGACTTTCTCTAC
TTCGCCAACTATGGCACAATACCAAAGTCACTTGCTTTGAGGATATGGGAAGAGTATCAGGACAGGGCCAGCAAAGATAA
ACTTCAGAAGTATCTGAGGAGATATCCCCGGTCGATAAGGAAGGTGGTTGAGAATGCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References