Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3776838..3777673 Replicon chromosome
Accession NZ_CP014583
Organism Escherichia coli strain CFSAN004176

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BCV59_RS20370 Protein ID WP_069357461.1
Coordinates 3776838..3777215 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag BCV59_RS20375 Protein ID WP_069357462.1
Coordinates 3777305..3777673 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCV59_RS20340 3772327..3773304 + 978 WP_000633205.1 type II secretion system minor pseudopilin GspK -
BCV59_RS20345 3773301..3774479 + 1179 WP_024226662.1 type II secretion system protein GspL -
BCV59_RS20350 3774481..3775017 + 537 WP_000942793.1 GspM family type II secretion system protein YghD -
BCV59_RS20355 3775347..3776189 - 843 WP_069357459.1 DUF4942 domain-containing protein -
BCV59_RS20360 3776274..3776465 - 192 WP_069357460.1 DUF957 domain-containing protein -
BCV59_RS31225 3776477..3776841 - 365 Protein_3636 hypothetical protein -
BCV59_RS20370 3776838..3777215 - 378 WP_069357461.1 TA system toxin CbtA family protein Toxin
BCV59_RS20375 3777305..3777673 - 369 WP_069357462.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BCV59_RS20380 3777748..3777969 - 222 WP_069357463.1 DUF987 domain-containing protein -
BCV59_RS20385 3778032..3778508 - 477 WP_069357464.1 RadC family protein -
BCV59_RS20390 3778524..3779009 - 486 WP_069357465.1 antirestriction protein -
BCV59_RS20410 3780420..3781274 + 855 Protein_3643 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14162.28 Da        Isoelectric Point: 7.7294

>T61537 WP_069357461.1 NZ_CP014583:c3777215-3776838 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T61537 NZ_CP014583:c3777215-3776838 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCATGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCCGGGTTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13722.52 Da        Isoelectric Point: 6.7395

>AT61537 WP_069357462.1 NZ_CP014583:c3777673-3777305 [Escherichia coli]
VSDTLHETTHPDDNRGRPWWGLPCTVTPCFGARMVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT61537 NZ_CP014583:c3777673-3777305 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTATGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References