Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1945764..1946224 Replicon chromosome
Accession NZ_CP014566
Organism Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag AZH48_RS09045 Protein ID WP_003408531.1
Coordinates 1945976..1946224 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag AZH48_RS09040 Protein ID WP_003408528.1
Coordinates 1945764..1945976 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZH48_RS09025 1942242..1943429 - 1188 WP_003898992.1 nitrate transporter NarK -
AZH48_RS09030 1943716..1944000 + 285 WP_003408522.1 DUF1876 domain-containing protein -
AZH48_RS09035 1944014..1945696 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
AZH48_RS09040 1945764..1945976 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AZH48_RS09045 1945976..1946224 + 249 WP_003408531.1 hypothetical protein Toxin
AZH48_RS09050 1946248..1946970 + 723 WP_003910424.1 hypothetical protein -
AZH48_RS09055 1947064..1948764 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
AZH48_RS09060 1949049..1949450 - 402 WP_010950586.1 hypothetical protein -
AZH48_RS09065 1949521..1950051 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T61469 WP_003408531.1 NZ_CP014566:1945976-1946224 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T61469 NZ_CP014566:1945976-1946224 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT61469 WP_003408528.1 NZ_CP014566:1945764-1945976 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT61469 NZ_CP014566:1945764-1945976 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References