Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4359058..4359689 | Replicon | chromosome |
Accession | NZ_CP014474 | ||
Organism | Serratia rubidaea strain 1122 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | L0MF14 |
Locus tag | AXX16_RS20035 | Protein ID | WP_015671220.1 |
Coordinates | 4359486..4359689 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A140F0B9 |
Locus tag | AXX16_RS20030 | Protein ID | WP_061324804.1 |
Coordinates | 4359058..4359426 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AXX16_RS20010 | 4355076..4355330 | + | 255 | WP_015671227.1 | type B 50S ribosomal protein L31 | - |
AXX16_RS23140 | 4355340..4355480 | + | 141 | WP_004940304.1 | type B 50S ribosomal protein L36 | - |
AXX16_RS20015 | 4355579..4356454 | - | 876 | WP_061324801.1 | metal ABC transporter substrate-binding protein | - |
AXX16_RS20020 | 4356470..4357336 | - | 867 | WP_061324802.1 | metal ABC transporter permease | - |
AXX16_RS20025 | 4357333..4358037 | - | 705 | WP_061324803.1 | ABC transporter ATP-binding protein | - |
AXX16_RS23820 | 4358034..4358183 | - | 150 | WP_158510627.1 | hypothetical protein | - |
AXX16_RS23145 | 4358348..4358701 | + | 354 | WP_071889352.1 | hypothetical protein | - |
AXX16_RS20030 | 4359058..4359426 | + | 369 | WP_061324804.1 | Hha toxicity modulator TomB | Antitoxin |
AXX16_RS20035 | 4359486..4359689 | + | 204 | WP_015671220.1 | hemolysin expression modulator Hha | Toxin |
AXX16_RS20040 | 4359770..4360702 | - | 933 | WP_061324805.1 | LysR family transcriptional regulator | - |
AXX16_RS20045 | 4360840..4362627 | + | 1788 | WP_061324806.1 | adenine deaminase | - |
AXX16_RS20050 | 4362697..4364040 | + | 1344 | WP_061324807.1 | NCS2 family permease | - |
AXX16_RS20055 | 4364075..4364497 | - | 423 | WP_015671216.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8049.33 Da Isoelectric Point: 7.9816
>T61243 WP_015671220.1 NZ_CP014474:4359486-4359689 [Serratia rubidaea]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
Download Length: 204 bp
>T61243 NZ_CP014474:4359486-4359689 [Serratia rubidaea]
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCACCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCACCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14393.20 Da Isoelectric Point: 4.7790
>AT61243 WP_061324804.1 NZ_CP014474:4359058-4359426 [Serratia rubidaea]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKRRLFRMFSGEVCCTKMKT
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKRRLFRMFSGEVCCTKMKT
Download Length: 369 bp
>AT61243 NZ_CP014474:4359058-4359426 [Serratia rubidaea]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCATCACGGCTGGGTTAACGATCCGACTTCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGGCGACT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCATCACGGCTGGGTTAACGATCCGACTTCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGGCGACT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A857EAE6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140F0B9 |