Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4359058..4359689 Replicon chromosome
Accession NZ_CP014474
Organism Serratia rubidaea strain 1122

Toxin (Protein)


Gene name Hha Uniprot ID L0MF14
Locus tag AXX16_RS20035 Protein ID WP_015671220.1
Coordinates 4359486..4359689 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A140F0B9
Locus tag AXX16_RS20030 Protein ID WP_061324804.1
Coordinates 4359058..4359426 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXX16_RS20010 4355076..4355330 + 255 WP_015671227.1 type B 50S ribosomal protein L31 -
AXX16_RS23140 4355340..4355480 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
AXX16_RS20015 4355579..4356454 - 876 WP_061324801.1 metal ABC transporter substrate-binding protein -
AXX16_RS20020 4356470..4357336 - 867 WP_061324802.1 metal ABC transporter permease -
AXX16_RS20025 4357333..4358037 - 705 WP_061324803.1 ABC transporter ATP-binding protein -
AXX16_RS23820 4358034..4358183 - 150 WP_158510627.1 hypothetical protein -
AXX16_RS23145 4358348..4358701 + 354 WP_071889352.1 hypothetical protein -
AXX16_RS20030 4359058..4359426 + 369 WP_061324804.1 Hha toxicity modulator TomB Antitoxin
AXX16_RS20035 4359486..4359689 + 204 WP_015671220.1 hemolysin expression modulator Hha Toxin
AXX16_RS20040 4359770..4360702 - 933 WP_061324805.1 LysR family transcriptional regulator -
AXX16_RS20045 4360840..4362627 + 1788 WP_061324806.1 adenine deaminase -
AXX16_RS20050 4362697..4364040 + 1344 WP_061324807.1 NCS2 family permease -
AXX16_RS20055 4364075..4364497 - 423 WP_015671216.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-117)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8049.33 Da        Isoelectric Point: 7.9816

>T61243 WP_015671220.1 NZ_CP014474:4359486-4359689 [Serratia rubidaea]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T61243 NZ_CP014474:4359486-4359689 [Serratia rubidaea]
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCACCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14393.20 Da        Isoelectric Point: 4.7790

>AT61243 WP_061324804.1 NZ_CP014474:4359058-4359426 [Serratia rubidaea]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKRRLFRMFSGEVCCTKMKT

Download         Length: 369 bp

>AT61243 NZ_CP014474:4359058-4359426 [Serratia rubidaea]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCATCACGGCTGGGTTAACGATCCGACTTCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGGCGACT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A857EAE6


Antitoxin

Source ID Structure
AlphaFold DB A0A140F0B9

References