Detailed information of TA system TA061145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2133211..2133510
• Replicon: chromosome
• Accession: NZ_CP014432
• Organism: Staphylococcus aureus strain USA300-SUR20

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AYM33_RS11215
• Protein ID: WP_011447039.1
• Coordinates: 2133334..2133510 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2133211..2133266 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM33_RS11160	2128542..2128802	+	261	WP_001791826.1	hypothetical protein	-
AYM33_RS11165	2128855..2129205	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AYM33_RS11170	2129890..2130339	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AYM33_RS15755	2130434..2130769	-	336	Protein_2065	SH3 domain-containing protein	-
AYM33_RS11195	2131419..2131910	-	492	WP_000919350.1	staphylokinase	-
AYM33_RS11200	2132101..2132856	-	756	WP_000861038.1	CHAP domain-containing protein	-
AYM33_RS11205	2132868..2133122	-	255	WP_000611512.1	phage holin	-
AYM33_RS11210	2133174..2133281	+	108	WP_001791821.1	hypothetical protein	-
-	2133203..2133342	+	140	NuclAT_0	-	-
-	2133203..2133342	+	140	NuclAT_0	-	-
-	2133203..2133342	+	140	NuclAT_0	-	-
-	2133203..2133342	+	140	NuclAT_0	-	-
-	2133211..2133266	+	56	-	-	Antitoxin
AYM33_RS11215	2133334..2133510	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AYM33_RS11220	2133660..2133956	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AYM33_RS11225	2134014..2134301	-	288	WP_001040261.1	hypothetical protein	-
AYM33_RS11230	2134348..2134500	-	153	WP_001153681.1	hypothetical protein	-
AYM33_RS11235	2134490..2138275	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2128855..2184803	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T61145 WP_011447039.1 NZ_CP014432:c2133510-2133334 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T61145 NZ_CP014432:c2133510-2133334 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT61145 NZ_CP014432:2133211-2133266 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin