Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2276705..2277536 Replicon chromosome
Accession NZ_CP014316
Organism Escherichia coli JJ1887

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AX202_RS11790 Protein ID WP_000854815.1
Coordinates 2277162..2277536 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AX202_RS11785 Protein ID WP_001280918.1
Coordinates 2276705..2277073 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX202_RS11740 2271794..2272540 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
AX202_RS11745 2272623..2272973 + 351 Protein_2254 hypothetical protein -
AX202_RS11750 2272989..2273399 + 411 WP_000846703.1 hypothetical protein -
AX202_RS11755 2273620..2274438 + 819 WP_001542275.1 DUF945 domain-containing protein -
AX202_RS11760 2274438..2274683 + 246 WP_001164966.1 hypothetical protein -
AX202_RS11765 2274777..2275250 + 474 WP_001542276.1 antirestriction protein -
AX202_RS11770 2275266..2275742 + 477 WP_001186200.1 RadC family protein -
AX202_RS11775 2275805..2276026 + 222 WP_000692345.1 DUF987 domain-containing protein -
AX202_RS11780 2276045..2276689 + 645 WP_000086752.1 hypothetical protein -
AX202_RS11785 2276705..2277073 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AX202_RS11790 2277162..2277536 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AX202_RS11795 2277533..2277727 + 195 WP_000988600.1 hypothetical protein -
AX202_RS30425 2277740..2277853 + 114 WP_001161660.1 DUF957 domain-containing protein -
AX202_RS11805 2278142..2278288 - 147 Protein_2266 transposase domain-containing protein -
AX202_RS11810 2278342..2278524 + 183 WP_001296208.1 hypothetical protein -
AX202_RS11815 2278625..2278954 - 330 WP_000450409.1 DUF496 family protein -
AX202_RS11820 2279126..2280184 - 1059 WP_001200889.1 FUSC family protein -
AX202_RS11825 2280382..2280855 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
AX202_RS11830 2280974..2282140 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T60709 WP_000854815.1 NZ_CP014316:2277162-2277536 [Escherichia coli JJ1887]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T60709 NZ_CP014316:2277162-2277536 [Escherichia coli JJ1887]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT60709 WP_001280918.1 NZ_CP014316:2276705-2277073 [Escherichia coli JJ1887]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT60709 NZ_CP014316:2276705-2277073 [Escherichia coli JJ1887]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References