60637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 5474105..5474636 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name relE Uniprot ID A0A126P2C7
Locus tag AXW83_RS26140 Protein ID WP_066619422.1
Coordinates 5474105..5474386 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A126P2Z4
Locus tag AXW83_RS26145 Protein ID WP_066619425.1
Coordinates 5474373..5474636 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS26115 (AXW83_26110) 5469502..5471007 + 1506 WP_066619408.1 glucose-6-phosphate dehydrogenase -
AXW83_RS26120 (AXW83_26115) 5471007..5471708 + 702 WP_066619414.1 6-phosphogluconolactonase -
AXW83_RS26125 (AXW83_26120) 5471739..5472383 + 645 WP_066619416.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
AXW83_RS26130 (AXW83_26125) 5472597..5472938 - 342 WP_156640448.1 hypothetical protein -
AXW83_RS26135 (AXW83_26130) 5472950..5474056 - 1107 WP_066619420.1 NAD(P)/FAD-dependent oxidoreductase -
AXW83_RS26140 (AXW83_26135) 5474105..5474386 - 282 WP_066619422.1 type II toxin-antitoxin system YafQ family toxin Toxin
AXW83_RS26145 (AXW83_26140) 5474373..5474636 - 264 WP_066619425.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXW83_RS26150 (AXW83_26145) 5474720..5475892 - 1173 WP_066619427.1 amidohydrolase -
AXW83_RS26155 (AXW83_26150) 5476225..5477277 + 1053 WP_066619429.1 DUF2778 domain-containing protein -
AXW83_RS26160 (AXW83_26155) 5477335..5477973 - 639 WP_066619431.1 VOC family protein -
AXW83_RS26165 (AXW83_26160) 5478014..5478352 - 339 WP_066621323.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
AXW83_RS26170 (AXW83_26165) 5478438..5479406 - 969 WP_066619433.1 pyridoxal-phosphate dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10725.28 Da        Isoelectric Point: 8.5406

>T60637 WP_066619422.1 NZ_CP014301:c5474386-5474105 [Bosea sp. PAMC 26642]
VRTIERTGQFKRDYKREAKGRHAATLDRDLVTIVGALAQDQPLLPRQRDHALTGEWKDHRDCHIRPDLVLIYCKPDEQTL
VLVRMGSHSELGL

Download         Length: 282 bp

>T60637 NZ_CP014301:c5474386-5474105 [Bosea sp. PAMC 26642]
GTGCGGACGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGGGAAGCCAAAGGCCGACATGCCGCCACTCTGGA
TCGTGATCTTGTCACCATCGTCGGCGCCCTTGCGCAGGATCAGCCCTTGCTCCCACGCCAGCGCGATCATGCGCTCACCG
GCGAGTGGAAAGACCATCGTGACTGCCATATCAGGCCGGATCTTGTACTGATCTATTGCAAGCCGGACGAGCAGACGCTG
GTGCTCGTCCGCATGGGCTCTCACAGCGAACTGGGGCTGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9465.98 Da        Isoelectric Point: 4.8011

>AT60637 WP_066619425.1 NZ_CP014301:c5474636-5474373 [Bosea sp. PAMC 26642]
MTENAVVRARIAEDVKSEATAVLATMGLTASDAFRMMMVRIAREKALPFEPLVPNEATIAAMREARGGKLPRFDTVGALM
DDLRADD

Download         Length: 264 bp

>AT60637 NZ_CP014301:c5474636-5474373 [Bosea sp. PAMC 26642]
ATGACAGAGAATGCCGTCGTCCGCGCCCGTATCGCCGAGGATGTGAAGTCCGAAGCGACCGCCGTACTTGCGACCATGGG
GCTGACAGCCTCCGACGCTTTCCGGATGATGATGGTCCGGATCGCACGCGAGAAGGCCCTGCCCTTCGAGCCGCTGGTTC
CCAACGAAGCGACGATCGCGGCGATGCGCGAAGCACGCGGAGGCAAGTTGCCTCGTTTCGACACCGTCGGTGCTCTGATG
GACGACCTGCGTGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126P2C7

Antitoxin

Source ID Structure
AlphaFold DB A0A126P2Z4

References