60628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 506878..507431 Replicon chromosome
Accession NZ_CP014301
Organism Bosea sp. PAMC 26642 strain PAMC26642

Toxin (Protein)


Gene name relE Uniprot ID A0A126NQQ8
Locus tag AXW83_RS02380 Protein ID WP_066610292.1
Coordinates 507138..507431 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A126NR37
Locus tag AXW83_RS02375 Protein ID WP_066610290.1
Coordinates 506878..507150 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW83_RS02350 (AXW83_02350) 501938..502609 - 672 WP_066610283.1 hypothetical protein -
AXW83_RS02355 (AXW83_02355) 502842..504062 + 1221 WP_082766900.1 MFS transporter -
AXW83_RS02360 (AXW83_02360) 504272..505048 + 777 WP_066610284.1 transporter substrate-binding domain-containing protein -
AXW83_RS02365 (AXW83_02365) 505371..506099 + 729 WP_066610286.1 ABC transporter permease subunit -
AXW83_RS02370 (AXW83_02370) 506096..506812 + 717 WP_066610287.1 ABC transporter permease subunit -
AXW83_RS02375 (AXW83_02375) 506878..507150 + 273 WP_066610290.1 CopG family ribbon-helix-helix protein Antitoxin
AXW83_RS02380 (AXW83_02380) 507138..507431 + 294 WP_066610292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXW83_RS02385 (AXW83_02385) 507560..508426 + 867 WP_066610294.1 NAD(P)-dependent oxidoreductase -
AXW83_RS02390 (AXW83_02390) 508534..510198 - 1665 WP_082767439.1 TRAP transporter large permease subunit -
AXW83_RS02395 (AXW83_02395) 510374..510970 - 597 WP_156639706.1 TRAP transporter small permease subunit -
AXW83_RS02400 (AXW83_02400) 511088..512275 - 1188 WP_066610299.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10969.56 Da        Isoelectric Point: 8.0213

>T60628 WP_066610292.1 NZ_CP014301:507138-507431 [Bosea sp. PAMC 26642]
MPQIAFTRAASLGVERCRRFLDPTNPRAARMATEAILRRIAILATHPGIGRPLSGEGELRELLISYGESGYVALYRYDLG
TDTVFLLAFRHQREEDY

Download         Length: 294 bp

>T60628 NZ_CP014301:507138-507431 [Bosea sp. PAMC 26642]
TTGCCACAGATAGCCTTTACGCGGGCTGCAAGCCTCGGCGTTGAACGCTGCCGCCGTTTCCTTGATCCGACAAACCCTCG
CGCTGCCAGGATGGCTACGGAGGCAATTCTTCGACGTATTGCGATTCTCGCAACGCATCCCGGTATCGGGCGGCCGCTGT
CTGGGGAGGGTGAGCTGCGGGAACTCCTGATCAGCTACGGCGAATCCGGATATGTCGCCCTTTACCGATATGATCTCGGC
ACTGATACGGTGTTCCTCCTCGCTTTTCGCCACCAGCGCGAGGAGGACTACTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10306.53 Da        Isoelectric Point: 4.4279

>AT60628 WP_066610290.1 NZ_CP014301:506878-507150 [Bosea sp. PAMC 26642]
MDTLLDIDPKLKVRIRELAERQQRSAGSVIVEAIEQYVARAEARLGFQQEALESWRDFQETGLHLTFEEVSAWLDTWGTD
AEGPPPPCHR

Download         Length: 273 bp

>AT60628 NZ_CP014301:506878-507150 [Bosea sp. PAMC 26642]
ATGGACACATTGCTCGACATTGATCCGAAACTTAAGGTTCGTATTCGCGAACTTGCCGAGCGCCAGCAGCGCTCGGCCGG
CTCGGTCATAGTCGAAGCGATCGAGCAATATGTGGCGCGCGCTGAGGCGCGGCTGGGTTTCCAGCAGGAAGCGCTTGAGT
CCTGGCGGGATTTTCAGGAGACGGGCCTTCACCTCACATTTGAGGAAGTCAGCGCTTGGTTGGACACTTGGGGTACTGAT
GCTGAAGGCCCACCGCCGCCTTGCCACAGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126NQQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A126NR37

References