Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1176544..1176766 Replicon chromosome
Accession NZ_CP014270
Organism Escherichia coli K-12 strain K-12 DHB4

Toxin (Protein)


Gene name ldrD Uniprot ID D3H2K1
Locus tag DHB4_RS05895 Protein ID WP_000170955.1
Coordinates 1176544..1176651 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1176699..1176766 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHB4_RS05865 1172400..1173233 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
DHB4_RS05870 1173230..1173622 + 393 WP_000200374.1 invasion regulator SirB2 -
DHB4_RS05875 1173626..1174435 + 810 WP_001257044.1 invasion regulator SirB1 -
DHB4_RS05880 1174471..1175325 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
DHB4_RS05885 1175474..1175581 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 1175629..1175695 + 67 NuclAT_34 - -
- 1175629..1175695 + 67 NuclAT_34 - -
- 1175629..1175695 + 67 NuclAT_34 - -
- 1175629..1175695 + 67 NuclAT_34 - -
- 1175629..1175695 + 67 NuclAT_36 - -
- 1175629..1175695 + 67 NuclAT_36 - -
- 1175629..1175695 + 67 NuclAT_36 - -
- 1175629..1175695 + 67 NuclAT_36 - -
- 1175629..1175695 + 67 NuclAT_38 - -
- 1175629..1175695 + 67 NuclAT_38 - -
- 1175629..1175695 + 67 NuclAT_38 - -
- 1175629..1175695 + 67 NuclAT_38 - -
- 1175629..1175695 + 67 NuclAT_40 - -
- 1175629..1175695 + 67 NuclAT_40 - -
- 1175629..1175695 + 67 NuclAT_40 - -
- 1175629..1175695 + 67 NuclAT_40 - -
- 1175629..1175695 + 67 NuclAT_42 - -
- 1175629..1175695 + 67 NuclAT_42 - -
- 1175629..1175695 + 67 NuclAT_42 - -
- 1175629..1175695 + 67 NuclAT_42 - -
- 1175629..1175695 + 67 NuclAT_44 - -
- 1175629..1175695 + 67 NuclAT_44 - -
- 1175629..1175695 + 67 NuclAT_44 - -
- 1175629..1175695 + 67 NuclAT_44 - -
- 1175631..1175696 + 66 NuclAT_18 - -
- 1175631..1175696 + 66 NuclAT_18 - -
- 1175631..1175696 + 66 NuclAT_18 - -
- 1175631..1175696 + 66 NuclAT_18 - -
- 1175631..1175696 + 66 NuclAT_21 - -
- 1175631..1175696 + 66 NuclAT_21 - -
- 1175631..1175696 + 66 NuclAT_21 - -
- 1175631..1175696 + 66 NuclAT_21 - -
- 1175631..1175696 + 66 NuclAT_24 - -
- 1175631..1175696 + 66 NuclAT_24 - -
- 1175631..1175696 + 66 NuclAT_24 - -
- 1175631..1175696 + 66 NuclAT_24 - -
- 1175631..1175696 + 66 NuclAT_27 - -
- 1175631..1175696 + 66 NuclAT_27 - -
- 1175631..1175696 + 66 NuclAT_27 - -
- 1175631..1175696 + 66 NuclAT_27 - -
- 1175631..1175696 + 66 NuclAT_30 - -
- 1175631..1175696 + 66 NuclAT_30 - -
- 1175631..1175696 + 66 NuclAT_30 - -
- 1175631..1175696 + 66 NuclAT_30 - -
- 1175631..1175696 + 66 NuclAT_33 - -
- 1175631..1175696 + 66 NuclAT_33 - -
- 1175631..1175696 + 66 NuclAT_33 - -
- 1175631..1175696 + 66 NuclAT_33 - -
DHB4_RS05890 1176009..1176116 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 1176164..1176231 + 68 NuclAT_17 - -
- 1176164..1176231 + 68 NuclAT_17 - -
- 1176164..1176231 + 68 NuclAT_17 - -
- 1176164..1176231 + 68 NuclAT_17 - -
- 1176164..1176231 + 68 NuclAT_20 - -
- 1176164..1176231 + 68 NuclAT_20 - -
- 1176164..1176231 + 68 NuclAT_20 - -
- 1176164..1176231 + 68 NuclAT_20 - -
- 1176164..1176231 + 68 NuclAT_23 - -
- 1176164..1176231 + 68 NuclAT_23 - -
- 1176164..1176231 + 68 NuclAT_23 - -
- 1176164..1176231 + 68 NuclAT_23 - -
- 1176164..1176231 + 68 NuclAT_26 - -
- 1176164..1176231 + 68 NuclAT_26 - -
- 1176164..1176231 + 68 NuclAT_26 - -
- 1176164..1176231 + 68 NuclAT_26 - -
- 1176164..1176231 + 68 NuclAT_29 - -
- 1176164..1176231 + 68 NuclAT_29 - -
- 1176164..1176231 + 68 NuclAT_29 - -
- 1176164..1176231 + 68 NuclAT_29 - -
- 1176164..1176231 + 68 NuclAT_32 - -
- 1176164..1176231 + 68 NuclAT_32 - -
- 1176164..1176231 + 68 NuclAT_32 - -
- 1176164..1176231 + 68 NuclAT_32 - -
- 1176165..1176230 + 66 NuclAT_35 - -
- 1176165..1176230 + 66 NuclAT_35 - -
- 1176165..1176230 + 66 NuclAT_35 - -
- 1176165..1176230 + 66 NuclAT_35 - -
- 1176165..1176230 + 66 NuclAT_37 - -
- 1176165..1176230 + 66 NuclAT_37 - -
- 1176165..1176230 + 66 NuclAT_37 - -
- 1176165..1176230 + 66 NuclAT_37 - -
- 1176165..1176230 + 66 NuclAT_39 - -
- 1176165..1176230 + 66 NuclAT_39 - -
- 1176165..1176230 + 66 NuclAT_39 - -
- 1176165..1176230 + 66 NuclAT_39 - -
- 1176165..1176230 + 66 NuclAT_41 - -
- 1176165..1176230 + 66 NuclAT_41 - -
- 1176165..1176230 + 66 NuclAT_41 - -
- 1176165..1176230 + 66 NuclAT_41 - -
- 1176165..1176230 + 66 NuclAT_43 - -
- 1176165..1176230 + 66 NuclAT_43 - -
- 1176165..1176230 + 66 NuclAT_43 - -
- 1176165..1176230 + 66 NuclAT_43 - -
- 1176165..1176230 + 66 NuclAT_45 - -
- 1176165..1176230 + 66 NuclAT_45 - -
- 1176165..1176230 + 66 NuclAT_45 - -
- 1176165..1176230 + 66 NuclAT_45 - -
DHB4_RS05895 1176544..1176651 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC Toxin
- 1176699..1176766 + 68 NuclAT_16 - Antitoxin
- 1176699..1176766 + 68 NuclAT_16 - Antitoxin
- 1176699..1176766 + 68 NuclAT_16 - Antitoxin
- 1176699..1176766 + 68 NuclAT_16 - Antitoxin
- 1176699..1176766 + 68 NuclAT_19 - Antitoxin
- 1176699..1176766 + 68 NuclAT_19 - Antitoxin
- 1176699..1176766 + 68 NuclAT_19 - Antitoxin
- 1176699..1176766 + 68 NuclAT_19 - Antitoxin
- 1176699..1176766 + 68 NuclAT_22 - Antitoxin
- 1176699..1176766 + 68 NuclAT_22 - Antitoxin
- 1176699..1176766 + 68 NuclAT_22 - Antitoxin
- 1176699..1176766 + 68 NuclAT_22 - Antitoxin
- 1176699..1176766 + 68 NuclAT_25 - Antitoxin
- 1176699..1176766 + 68 NuclAT_25 - Antitoxin
- 1176699..1176766 + 68 NuclAT_25 - Antitoxin
- 1176699..1176766 + 68 NuclAT_25 - Antitoxin
- 1176699..1176766 + 68 NuclAT_28 - Antitoxin
- 1176699..1176766 + 68 NuclAT_28 - Antitoxin
- 1176699..1176766 + 68 NuclAT_28 - Antitoxin
- 1176699..1176766 + 68 NuclAT_28 - Antitoxin
- 1176699..1176766 + 68 NuclAT_31 - Antitoxin
- 1176699..1176766 + 68 NuclAT_31 - Antitoxin
- 1176699..1176766 + 68 NuclAT_31 - Antitoxin
- 1176699..1176766 + 68 NuclAT_31 - Antitoxin
DHB4_RS05900 1177055..1178155 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
DHB4_RS05905 1178425..1178655 + 231 WP_001146444.1 putative cation transport regulator ChaB -
DHB4_RS05910 1178813..1179508 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
DHB4_RS05915 1179552..1179905 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
DHB4_RS05920 1180090..1181484 + 1395 WP_000086217.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4013.82 Da        Isoelectric Point: 11.4779

>T60518 WP_000170955.1 NZ_CP014270:c1176651-1176544 [Escherichia coli K-12]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T60518 NZ_CP014270:c1176651-1176544 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT60518 NZ_CP014270:1176699-1176766 [Escherichia coli K-12]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J2A9

Antitoxin

Download structure file

References