Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2218201..2219762 Replicon chromosome
Accession NZ_CP014129
Organism Pantoea vagans strain FDAARGOS_160

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AL522_RS14365 Protein ID WP_061062483.1
Coordinates 2218201..2219514 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AL522_RS14370 Protein ID WP_061062484.1
Coordinates 2219514..2219762 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL522_RS14345 2213447..2213782 + 336 WP_061062479.1 gamma-glutamylcyclotransferase -
AL522_RS14350 2214124..2216169 - 2046 WP_061062480.1 FUSC family protein -
AL522_RS14355 2216284..2217666 - 1383 WP_061062481.1 M24 family metallopeptidase -
AL522_RS14360 2217890..2218096 - 207 WP_061062482.1 type II toxin-antitoxin system MqsA family antitoxin -
AL522_RS14365 2218201..2219514 - 1314 WP_061062483.1 type II toxin-antitoxin system HipA family toxin Toxin
AL522_RS14370 2219514..2219762 - 249 WP_061062484.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
AL522_RS14375 2219943..2220380 + 438 WP_061062485.1 GNAT family N-acetyltransferase -
AL522_RS14380 2220414..2221130 - 717 Protein_2063 inositol monophosphatase -
AL522_RS14385 2221127..2223199 - 2073 Protein_2064 iron ABC transporter permease -
AL522_RS14390 2223288..2224310 - 1023 WP_061062486.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49225.69 Da        Isoelectric Point: 8.4318

>T60223 WP_061062483.1 NZ_CP014129:c2219514-2218201 [Pantoea vagans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSLPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGKMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMLFQVFQWLTGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNRRALKLAMGLRATKGKKTEIDKIFPRHFIGTAKQVNFDRDSLQQIFDFFVREFP
KAVVSVREALPADFPQHIADAIFSHSLIMLERLRHND

Download         Length: 1314 bp

>T60223 NZ_CP014129:c2219514-2218201 [Pantoea vagans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTGCTTACCCGGCAGCGGAATGGCGCTCATGAGTTTCA
GTATGACACCGGCTGGCTGAGTAACCCGCTCTCCAGGCCGCTGTCACTTTCTCTGCCGTTGCAGGTTAAGGCGATTACCT
CACACGCCGTCATTAATTTCTTCGACAACCTGCTGCCGGATAGCCCGTTGATTCGTGACAGGATCGTGGCGCGTTACCAG
ATTAAATCTCGCCAGCCGTTTGACCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACCATGCTGTTGCCGCCCGA
TATGCCGCTGCCCGCACTGCAGGCTCGCTATGAGGTGCTGGATGAAGCCCGGCTCGAGAGCGTGCTTTCAGCCTATCAGT
CCGATATTCCGCTGGGGATGCTGCGTGAAGAGACCGACTTCCGCATTTCGGTGGCGGGCGCACAGGAGAAAACGGCGCTG
CTGCTGACCGAAGAGGGCTGGAGCATTCCTGCCGGCGCCACGCCCACCTCGCACATTATCAAGCTGCCAATCGGTGAAAT
TAAACAGCCAGCCGCGACGCTGGATATGCGTGAAAGCGTAGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGCGCACTGG
GTATTGATGTGCCGCAGGCGACGATTATCCGGGCCGGTAAGATGCGCGCCCTGGCCGTTGAGCGTTTTGATCGCCGCTGG
TCGCGCGACCGAACCCGCCTGATTCGTCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGGCTGCCATCCTCGACTAAATA
TGAGTCGGATGGCGGGCCGGGCATCGCAGAAATAATGCAGATACTGATGGGATCGAGCAACGCCATTGAGGATCGCTATC
GCTTTATGCTGTTCCAGGTGTTTCAGTGGCTGACGGGCGCAACCGACGGTCACGCTAAAAACTTCTCGCTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACACCCTTTTATGATGTGATCTCCGCTTATCCGGTGCTGGGCGGTACCGGCCTGAACAG
GCGTGCACTTAAACTGGCAATGGGGCTGCGTGCCACTAAGGGAAAGAAGACAGAAATCGACAAAATCTTTCCGCGCCATT
TTATCGGCACGGCGAAGCAGGTGAATTTTGATCGTGACAGCCTGCAGCAGATCTTTGACTTCTTCGTCCGTGAGTTTCCA
AAGGCGGTAGTCTCAGTGCGCGAGGCCTTACCGGCCGATTTCCCGCAGCACATCGCTGATGCAATCTTCAGCCATTCACT
GATTATGCTTGAGCGGTTACGGCATAACGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9275.59 Da        Isoelectric Point: 6.4622

>AT60223 WP_061062484.1 NZ_CP014129:c2219762-2219514 [Pantoea vagans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLDVVKKEEASAPQLHDED
DW

Download         Length: 249 bp

>AT60223 NZ_CP014129:c2219762-2219514 [Pantoea vagans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTTATCCGCCAGCGCAACGGCTGGACCCAGAGTGAACTGGC
AAAAAAGGTGGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATGCGCCTGACAGTACCTCGCTGGCCACGCTGTTTA
AGCTTTTACAGGCGCTGGAAGTGAGTCTGGACGTAGTGAAAAAAGAGGAGGCCAGTGCGCCTCAGTTGCATGATGAGGAT
GACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References