Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1254626..1255243 Replicon chromosome
Accession NZ_CP014129
Organism Pantoea vagans strain FDAARGOS_160

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag AL522_RS09565 Protein ID WP_003850458.1
Coordinates 1254626..1254841 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E1SGC9
Locus tag AL522_RS09570 Protein ID WP_013357010.1
Coordinates 1254866..1255243 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL522_RS09535 1250529..1250867 + 339 WP_003850469.1 P-II family nitrogen regulator -
AL522_RS09540 1250902..1252188 + 1287 WP_013357006.1 ammonium transporter AmtB -
AL522_RS09545 1252246..1253109 - 864 WP_061061842.1 acyl-CoA thioesterase II -
AL522_RS09550 1253300..1253857 + 558 WP_013357008.1 YbaY family lipoprotein -
AL522_RS09555 1253859..1254203 - 345 WP_013357009.1 MGMT family protein -
AL522_RS09565 1254626..1254841 - 216 WP_003850458.1 hemolysin expression modulator Hha Toxin
AL522_RS09570 1254866..1255243 - 378 WP_013357010.1 Hha toxicity modulator TomB Antitoxin
AL522_RS09575 1255391..1255744 - 354 WP_041456682.1 hypothetical protein -
AL522_RS09580 1256074..1256742 + 669 WP_061061843.1 ABC transporter ATP-binding protein -
AL522_RS09585 1256739..1257578 + 840 WP_061061844.1 metal ABC transporter permease -
AL522_RS09590 1257598..1258476 + 879 WP_061061845.1 metal ABC transporter substrate-binding protein -
AL522_RS09595 1258522..1258662 - 141 WP_009091664.1 type B 50S ribosomal protein L36 -
AL522_RS09600 1258674..1258928 - 255 WP_033782196.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T60221 WP_003850458.1 NZ_CP014129:c1254841-1254626 [Pantoea vagans]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T60221 NZ_CP014129:c1254841-1254626 [Pantoea vagans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGTTGCCGCTCTCTGGATACCCTGGAAAGGGTCAT
TGAAAAAAATAAGTATGAATTACCCGAGGATGAATTAGCGGTATTTTACTCTGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTTTATGATAAAGTCCCAGGTTCAGTATGGAAATTTGTCCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14650.28 Da        Isoelectric Point: 4.3976

>AT60221 WP_013357010.1 NZ_CP014129:c1255243-1254866 [Pantoea vagans]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGINSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT60221 NZ_CP014129:c1255243-1254866 [Pantoea vagans]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATATCTGTGTGAGAGCCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCACGGCTGGGTGAACGACCCCACTTCTGAAAGCAATCTGCAGCTTAACGATTTGATTGAAC
ACATTGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTCTTCAGCAACTATGGTATCAATAGTCCGGATCTTCAACGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7PH97

References