Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 40971..41554 Replicon plasmid unnamed3
Accession NZ_CP014128
Organism Pantoea vagans strain FDAARGOS_160

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AL522_RS02925 Protein ID WP_061060937.1
Coordinates 41276..41554 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AL522_RS02920 Protein ID WP_061060936.1
Coordinates 40971..41276 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL522_RS02905 36548..37720 - 1173 WP_033785272.1 FMNH2-dependent alkanesulfonate monooxygenase -
AL522_RS02910 37995..39884 + 1890 WP_061060934.1 sigma-54-dependent Fis family transcriptional regulator -
AL522_RS02915 39980..40927 + 948 WP_061060935.1 sulfonate ABC transporter substrate-binding protein -
AL522_RS02920 40971..41276 - 306 WP_061060936.1 HigA family addiction module antidote protein Antitoxin
AL522_RS02925 41276..41554 - 279 WP_061060937.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL522_RS02930 42115..43248 + 1134 WP_061060938.1 glutathione-independent formaldehyde dehydrogenase -
AL522_RS02940 43806..44075 + 270 Protein_40 type II toxin-antitoxin system RelE/ParE family toxin -
AL522_RS02945 44196..44509 - 314 Protein_41 HigA family addiction module antidote protein -
AL522_RS02950 44887..45505 + 619 Protein_42 DUF2913 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - pilW 1..197914 197914
- flank IS/Tn - pilW 46447..46761 314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10952.43 Da        Isoelectric Point: 8.5038

>T60219 WP_061060937.1 NZ_CP014128:c41554-41276 [Pantoea vagans]
MIKTWLHKGLEEFYTTGSTRKINAAHEKRLRTRLRVIDLAENIEDMNLSGYRLHPLKGDRQGIWSITVTGNWRITFEFKD
GDAWILNYEDYH

Download         Length: 279 bp

>T60219 NZ_CP014128:c41554-41276 [Pantoea vagans]
ATGATCAAAACCTGGCTACACAAGGGGCTTGAAGAGTTTTACACCACCGGCTCAACCAGAAAAATTAATGCAGCCCATGA
AAAACGGTTACGTACTCGCTTAAGGGTTATCGACCTTGCTGAAAATATTGAGGATATGAACCTCAGCGGCTACAGGCTGC
ATCCACTTAAAGGTGACAGACAAGGTATCTGGTCGATCACGGTCACAGGGAACTGGCGCATTACTTTTGAGTTTAAAGAT
GGGGATGCCTGGATTCTGAATTATGAGGATTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11017.77 Da        Isoelectric Point: 8.6057

>AT60219 WP_061060936.1 NZ_CP014128:c41276-40971 [Pantoea vagans]
MKMHNPPHAGEVISDIMEDLGIGIRELARALAIAPSTVSRMVSGTTAVTPEMAIRLSAVIGSTPEMWLRIQAAYDLDRAA
KKVDLSVLNSRYKPDQLRSTN

Download         Length: 306 bp

>AT60219 NZ_CP014128:c41276-40971 [Pantoea vagans]
ATGAAAATGCATAACCCCCCGCACGCTGGTGAAGTTATTTCCGATATCATGGAAGACCTCGGTATCGGGATCAGGGAACT
GGCTCGTGCTTTGGCAATTGCACCTTCGACTGTTTCCAGAATGGTTTCCGGAACTACTGCTGTCACCCCAGAAATGGCCA
TTAGATTATCTGCTGTGATCGGCAGTACACCTGAAATGTGGCTACGCATACAGGCGGCCTATGACCTTGACCGCGCAGCA
AAAAAAGTGGATTTAAGCGTGCTGAATAGCCGCTATAAGCCCGATCAGTTGCGGAGCACAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References