Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 21317..21581 Replicon plasmid unnamed1
Accession NZ_CP014096
Organism Shigella sonnei strain FDAARGOS_90

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag AL477_RS00110 Protein ID WP_001331364.1
Coordinates 21317..21469 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 21524..21581 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL477_RS00090 (16594) 16594..18762 + 2169 WP_000698357.1 DotA/TraY family protein -
AL477_RS00095 (18836) 18836..19486 + 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
AL477_RS00100 (19558) 19558..19767 - 210 WP_000062603.1 HEAT repeat domain-containing protein -
AL477_RS25780 (20159) 20159..20335 + 177 WP_001054898.1 hypothetical protein -
AL477_RS26665 (20400) 20400..20495 - 96 WP_001303310.1 DinQ-like type I toxin DqlB -
AL477_RS00105 (20994) 20994..21245 + 252 WP_001291964.1 hypothetical protein -
AL477_RS00110 (21317) 21317..21469 - 153 WP_001331364.1 Hok/Gef family protein Toxin
- (21524) 21524..21581 + 58 NuclAT_0 - Antitoxin
- (21524) 21524..21581 + 58 NuclAT_0 - Antitoxin
- (21524) 21524..21581 + 58 NuclAT_0 - Antitoxin
- (21524) 21524..21581 + 58 NuclAT_0 - Antitoxin
AL477_RS00115 (21761) 21761..22969 + 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
AL477_RS00120 (22988) 22988..24058 + 1071 WP_061066710.1 IncI1-type conjugal transfer protein TrbB -
AL477_RS00125 (24051) 24051..26342 + 2292 WP_077108717.1 F-type conjugative transfer protein TrbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..82828 82828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T60121 WP_001331364.1 NZ_CP014096:c21469-21317 [Shigella sonnei]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T60121 NZ_CP014096:c21469-21317 [Shigella sonnei]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT60121 NZ_CP014096:21524-21581 [Shigella sonnei]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References