Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56507..57032 Replicon plasmid unnamed
Accession NZ_CP014050
Organism Salmonella enterica strain FDAARGOS_94

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag AL463_RS00355 Protein ID WP_001159863.1
Coordinates 56727..57032 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag AL463_RS00350 Protein ID WP_000813641.1
Coordinates 56507..56725 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL463_RS00320 51794..52175 + 382 Protein_61 YgiW/YdeI family stress tolerance OB fold protein -
AL463_RS00325 52344..52788 + 445 Protein_62 site-specific integrase -
AL463_RS00330 53047..54036 - 990 WP_001527061.1 RepB family plasmid replication initiator protein -
AL463_RS00335 54530..54826 - 297 WP_001687482.1 hypothetical protein -
AL463_RS00345 55310..55831 - 522 WP_010999942.1 hypothetical protein -
AL463_RS00350 56507..56725 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
AL463_RS00355 56727..57032 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
AL463_RS00360 57034..57324 + 291 WP_001266176.1 hypothetical protein -
AL463_RS00365 57321..57842 + 522 WP_000198608.1 hypothetical protein -
AL463_RS00370 57877..58659 + 783 WP_000082169.1 site-specific integrase -
AL463_RS00375 58668..59381 + 714 Protein_71 EAL domain-containing protein -
AL463_RS00385 59385..59894 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
AL463_RS00390 59888..60373 + 486 WP_000905606.1 membrane protein -
AL463_RS25435 60650..60937 - 288 WP_071530243.1 hypothetical protein -
AL463_RS00395 61093..61653 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93933 93933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T60035 WP_001159863.1 NZ_CP014050:56727-57032 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T60035 NZ_CP014050:56727-57032 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT60035 WP_000813641.1 NZ_CP014050:56507-56725 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT60035 NZ_CP014050:56507-56725 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References