Detailed information of TA system TA059927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4035416..4036068
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AL485_RS19330
• Protein ID: WP_048762749.1
• Coordinates: 4035682..4036068 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A379YGI8
• Locus tag: AL485_RS19325
• Protein ID: WP_020828097.1
• Coordinates: 4035416..4035679 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS19310	4031805..4032722	-	918	WP_020828101.1	lipid kinase YegS	-
AL485_RS19315	4033196..4034548	-	1353	WP_041414820.1	tRNA 5-hydroxyuridine modification protein YegQ	-
AL485_RS19320	4034726..4035064	-	339	WP_020828098.1	YegP family protein	-
AL485_RS19325	4035416..4035679	+	264	WP_020828097.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AL485_RS19330	4035682..4036068	+	387	WP_048762749.1	type II toxin-antitoxin system VapC family toxin	Toxin
AL485_RS19335	4036073..4036789	-	717	WP_020828095.1	two-component system response regulator BaeR	-
AL485_RS19340	4036789..4038171	-	1383	WP_046372938.1	two-component system sensor histidine kinase BaeS	-
AL485_RS19345	4038171..4039601	-	1431	WP_020828093.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14077.28 Da
• Isoelectric Point: 7.8799

>T59927 WP_048762749.1 NZ_CP014017:4035682-4036068 [Serratia liquefaciens]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDAVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Nucleotide

• Length: 387 bp

>T59927 NZ_CP014017:4035682-4036068 [Serratia liquefaciens]
ATGTATATGTTTGACACCAATACGGTCAGCCAACTGTTCCGTCGGCATCCCCGCTTGCTGAGCCTAATGGAAAAAATCCC
GCCTTCTGCGGTATGCATTTCCAGCATTACGCAGGCGGAACTGCTTTATGGCGTAGCCAAGCGGCAGAACCTTGCGCTGA
AAGCGACGGTCGCGGCATTTCTTGATGCCGTGACGGTATATGCCTGGGACAGTGAAGCCGCGCATTGCTATGGCACGCTG
CGGGCGGAAATGACGCAAAAGGGGCGGGTGATGGGGGCCCTGGATCAGCTTATTGCCGCCCACGCGCAGAGCCGCGGAGC
GACAATAGTGACTAACGACCGGGCGTTTGCCATGGTGCCAGGCCTGACGGTAGAAGACTGGACCTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10091.38 Da
• Isoelectric Point: 5.8701

>AT59927 WP_020828097.1 NZ_CP014017:4035416-4035679 [Serratia liquefaciens]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Nucleotide

• Length: 264 bp

>AT59927 NZ_CP014017:4035416-4035679 [Serratia liquefaciens]
ATGGAAAGGGTCGCGAAACTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCCGTGGAATTCGAATTTGATACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGAAACGTGATTTTATCTAAATATCCGGCCAAACCTGACAGCTGGGCTCCGC
TGCTGCAAATGATCGAAAAAACGCAGGTACCGCATGACTTTCTGGCGGCTGATGAACGTCAGCAGGGCAGTGCCACCCGC
GATCCGTTCGCCGGGGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A379YGI8