Detailed information of TA system TA059925

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3613250..3613919
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AL485_RS17235
• Protein ID: WP_020828475.1
• Coordinates: 3613497..3613919 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: AL485_RS17230
• Protein ID: WP_020828476.1
• Coordinates: 3613250..3613516 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS17205	3608386..3609711	+	1326	WP_046372712.1	MHS family MFS transporter	-
AL485_RS17210	3609752..3610360	-	609	WP_048760837.1	HD domain-containing protein	-
AL485_RS17215	3610544..3611218	+	675	WP_048760835.1	hemolysin III family protein	-
AL485_RS17220	3611382..3611883	+	502	Protein_3302	DUF2165 domain-containing protein	-
AL485_RS17225	3611941..3612927	-	987	WP_048760833.1	tRNA-modifying protein YgfZ	-
AL485_RS17230	3613250..3613516	+	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
AL485_RS17235	3613497..3613919	+	423	WP_020828475.1	protein YgfX	Toxin
AL485_RS17240	3613919..3614614	+	696	WP_048760831.1	two-component system response regulator CreB	-
AL485_RS17245	3614611..3616029	+	1419	WP_048760829.1	two-component system sensor histidine kinase CreC	-
AL485_RS17250	3616114..3617478	+	1365	WP_048760827.1	cell envelope integrity protein CreD	-
AL485_RS17255	3617515..3618033	-	519	WP_020828471.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16577.54 Da
• Isoelectric Point: 10.6957

>T59925 WP_020828475.1 NZ_CP014017:3613497-3613919 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLVKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T59925 NZ_CP014017:3613497-3613919 [Serratia liquefaciens]
GTGGCCCAGTGGCGATGTGATGTTCGTATTTCCTGGCGCACCCAGTTACTTTCGCTGTTGACGCATGGCGTTCTGATCCT
GCTGATCCTGATTTCACCCTGGCCGGAAGGCTACGGGCCAATCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGTAGCCAAAAACGCATTGCGTCACGTCAGGGGGAGTTGCGCCTGCTGGAGAACCAGCGTGTGGGCTGGCAAGGCCAG
GAATGGCAGTTGGTCAAGCAACCCTGGATGCTGCGCTTCGGTATTCTGCTGACGTTGCAACCGATGCAGGGGAAAAAGCG
TCGTCGCTTATGGTTGGCTTCCGACAGCATGGCCAAGGCCGAATGGCGACATTTGCGCCAACAGCTGTTGTATCCGCCGG
CCAGTGATGATGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT59925 WP_020828476.1 NZ_CP014017:3613250-3613516 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT59925 NZ_CP014017:3613250-3613516 [Serratia liquefaciens]
ATGGATATTAATAACAAAGCACGTATTCACTGGGCTTGTCGCCGTGGCATGCGTGAGCTGGACATCTCGATCATGCCGTT
CTTCGAATATGAGTACGATCGGTTGAATGACACAGACAAAGCGCTGTTTATCCGCCTGCTTGAGAGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9